Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse

Khosrotehrani, Kiarash and Bianchi, Diana W. (2005) Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse. Journal of Cell Science, 118 8: 1559-1563. doi:10.1242/jcs.02332

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Author Khosrotehrani, Kiarash
Bianchi, Diana W.
Title Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
Publication date 2005-04-15
Sub-type Article (original research)
DOI 10.1242/jcs.02332
Open Access Status File (Publisher version)
Volume 118
Issue 8
Start page 1559
End page 1563
Total pages 5
Place of publication Cambridge
Publisher Company of Biologists
Language eng
Subject 111401 Foetal Development and Medicine
111402 Obstetrics and Gynaecology
Abstract Fetal cells circulate in pregnant women and persist in blood and tissue for decades post-partum. The mother thus becomes chimeric. Factors that may influence such fetal cell microchimerism include histocompatibility, fetal or placental abnormalities, or a reproductive history that includes miscarriage or elective termination. Fetal cell microchimerism is associated with some maternal autoimmune diseases, such as systemic sclerosis. Moreover, a novel population of fetal cells, the pregnancy-associated progenitor cells (PAPCs), appears to differentiate in diseased or injured maternal tissue. The cellular origin of these cells is at present unknown but could be a hematopoietic stem cell, a mesenchymal stem cell, or a novel cell type. Pregnancy therefore results in the acquisition of cells with stem-cell-like properties that may influence maternal health post-partum. Rather than triggering disease, these cells may instead combat it.
Keyword Stem cells
Fetal cell microchimerism
Pregnancy-associated progenitor cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 87 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 109 times in Scopus Article | Citations
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Created: Tue, 17 Nov 2009, 12:27:21 EST