A new hazard index of complex mixtures integrates bioconcentration and toxicity to refine the environmental risk assessment of effluents

Gutierrez, Simon, Fernandez, Carlos, Escher, Beate I. and Tarazona, Jose Vincente (2008) A new hazard index of complex mixtures integrates bioconcentration and toxicity to refine the environmental risk assessment of effluents. Environment International, 34 6: 773-781. doi:10.1016/j.envint.2008.01.002

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Author Gutierrez, Simon
Fernandez, Carlos
Escher, Beate I.
Tarazona, Jose Vincente
Title A new hazard index of complex mixtures integrates bioconcentration and toxicity to refine the environmental risk assessment of effluents
Journal name Environment International   Check publisher's open access policy
ISSN 0160-4120
1873-6750
Publication date 2008-08
Sub-type Article (original research)
DOI 10.1016/j.envint.2008.01.002
Volume 34
Issue 6
Start page 773
End page 781
Total pages 9
Place of publication Oxford ; New York ; Frankfurt
Publisher Pergamon Press
Language eng
Subject 05 Environmental Sciences
0502 Environmental Science and Management
Abstract A new methodology to evaluate the overall environmental hazard of unknown mixtures, based on bioconcentration potential and toxicity, was developed using a combination of two methodologies: 1) the estimation of the octanol–water partition coefficient (Kow) using reverse-phase high performance liquid chromatography (RP–HPLC) and 2) the toxicity identification evaluation (TIE). Forty seven compounds with known Kow and different molecular structures where used for the calibration of the log Kow in relation to the retention time in reverse-phase high performance liquid chromatography (RP–HPLC). A linear regression with an R2 = 0.81 and an sd = 0.69 was established between log Kow and RP–HPLC retention time. This Kow estimation method was furthermore validated using seven additional compounds, showing acceptable estimations of the log Kow of unknown substances. Two different mixtures were tested, one containing 3,4 Dichloroaniline, Diazinon and 4-Nonylphenol and another one containing a mixture of 16 pesticides. Both mixtures were first tested as a whole effluent and then fractionated and tested, using a miniaturized Daphnia magna test. An equation is presented, that combines both methodologies and establishes a relative hazard index RHI, ranging from 1 to 10 for any particular mixture of chemicals. The results show how the method presented can refine the security factors that could be included in the environmental risk assessment of effluents in the future.
Keyword Bioconcentration
Environmental risk assessment
Effluents
Toxicity
Water partition-coefficients
Performance liquid-chromatography
Effect-directed analysis
Physiochemcial properies
Aromatic-compounds
Organic-compounds
Identification
Chemicals
Bioaccumulation
Components
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
National Research Centre for Environmental Toxicology Publications
 
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Created: Tue, 17 Nov 2009, 09:47:20 EST