Effect of levetiracetam on cortical excitability: A transcranial magnetic stimulation study

Solinas, C., Lee, Y.C. and Reutens, D.C. (2008) Effect of levetiracetam on cortical excitability: A transcranial magnetic stimulation study. European Journal of Neurology, 15 5: 501-505. doi:10.1111/j.1468-1331.2008.02110.x


Author Solinas, C.
Lee, Y.C.
Reutens, D.C.
Title Effect of levetiracetam on cortical excitability: A transcranial magnetic stimulation study
Journal name European Journal of Neurology   Check publisher's open access policy
ISSN 1351-5101
1468-1331
Publication date 2008-05
Sub-type Article (original research)
DOI 10.1111/j.1468-1331.2008.02110.x
Open Access Status
Volume 15
Issue 5
Start page 501
End page 505
Total pages 5
Place of publication Malden, MA, U.S.A.
Publisher Wiley Interscience
Language eng
Subject 11 Medical and Health Sciences
1109 Neurosciences
Formatted abstract
Background and purpose:
We studied the effect of levetiracetam (LEV), an anticonvulsant with a novel mechanism of action, on cortical excitability, measured using transcranial magnetic stimulation (TMS). For this purpose, 38 healthy volunteers were assessed in two TMS sessions, before and after an oral dose of 3000 mg LEV.

Methods:

Resting motor threshold (RMT), intracortical facilitation (ICF) and intracortical inhibition (ICI), cortical silent period (CSP) threshold and duration and motor-evoked potential (MEP) amplitude were calculated.

Results:

After treatment with LEV, RMT was increased (mean ± SD: 63 ± 14% of the maximum stimulator output) compared with baseline (58 ± 11%). CSP threshold was decreased after LEV (54 ± 10%; baseline, 57 ± 11%). CSP duration was increased after LEV (116 ± 37 ms; baseline: 102 ± 33 ms). LEV did not affect ICF or ICI or mean MEP amplitude significantly.

Conclusions:
Our results indicate that LEV modulates some aspects of cortical excitability. Whereas the increase in the RMT most probably reflects the effect of LEV on ion channel activity, effects on the CSP might represent a modulation of GABA receptors at cortical and spinal level.
Keyword Cortical Excitability
Cortical Silent Period
Levetiracetam
Resting Motor Threshold
Transcranial Magnetic Stimulation
Antiepiletic Drug Levetiracetam
Motor Cortex Excitability
Silent Period
Binding-site
Gaba Uptake
Currents
Humans
Inhibition
Baclofen
Brain
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Created: Fri, 13 Nov 2009, 08:06:07 EST