Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans

Hofle, N., Paus, T., Reutens, D., Fiset, P., Gotman, J., Evans, A. C. and Jones, B. E. (1997) Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans. Journal of Neuroscience, 17 12: 4800-4808.

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Author Hofle, N.
Paus, T.
Reutens, D.
Fiset, P.
Gotman, J.
Evans, A. C.
Jones, B. E.
Title Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 1997-06
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 17
Issue 12
Start page 4800
End page 4808
Total pages 9
Editor John H. R. Maunsell
Place of publication New York , U.S.A.
Publisher Society for Neuroscience
Language eng
Subject 1109 Neurosciences
110904 Neurology and Neuromuscular Diseases
Abstract In the present study, we investigated changes in regional cerebral blood flow (rCBF) in humans during the progression from relaxed wakefulness through slow wave sleep (SWS). These changes were examined as a function of spindle (12-15 Hz) and delta (1.5-4.0 Hz) electroencephalographic (EEG) activity of SWS. rCBF was studied with positron emission tomography (PET) using the H215O bolus method. A maximum of six 60 sec scans were performed per subject during periods of wakefulness and stages 1-4 of SWS, as determined by on-line EEG monitoring. Spectral analysis was performed off-line on the EEG epochs corresponding to the scans for computation of activity in specific frequency bands. The relationship between EEG frequency band activity and normalized rCBF was determined by means of a voxel-by-voxel analysis of covariance. delta activity covaried negatively with rCBF most markedly in the thalamus and also in the brainstem reticular formation, cerebellum, anterior cingulate, and orbitofrontal cortex. After the effect of delta was removed, a significant negative covariation between spindle activity and the residual rCBF was evident in the medial thalamus. These negative covariations may reflect the disfacilitation and active inhibition of thalamocortical relay neurons in association with delta and spindles, as well as the neural substrates underlying the progressive attenuation of sensory awareness, motor responsiveness, and arousal that occur during SWS. delta activity covaried positively with rCBF in the visual and auditory cortex, possibly reflecting processes of dream-like mentation purported to occur during SWS
Keyword Reticular formation
Visual cortex
Positron Emission Tomography
Nucleus Reticularis Thalami
Eye-Movement sleep
Intravenous (H2O)-O-15
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 215 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 13 Nov 2009, 08:03:09 EST