Airway smooth muscle proliferation in asthma: The potential of vascular leakage to contribute to pathogenesis

Shiels, I. A., Bowler, S. D. and Taylor, S. M. (1995) Airway smooth muscle proliferation in asthma: The potential of vascular leakage to contribute to pathogenesis. Medical Hypothesis, 45 1: 37-40.


Author Shiels, I. A.
Bowler, S. D.
Taylor, S. M.
Title Airway smooth muscle proliferation in asthma: The potential of vascular leakage to contribute to pathogenesis
Journal name Medical Hypothesis   Check publisher's open access policy
Publication date 1995-07
Sub-type Article
DOI 10.1016/0306-9877(95)90198-1
Volume number 45
Issue number 1
ISSN 0306-9877
Start page 37
End page 40
Total pages 4
Place of publication Edinburgh, Scotland
Publisher Churchill Livingstone
Language eng
Subject 111601 Cell Physiology
1116 Medical Physiology
110203 Respiratory Diseases
Abstract Proliferation of the non-vascular smooth muscle in the walls of the bronchi and bronchioles is a prominent histopathological feature of asthma and is thought to contribute to airway hyperreactivity and narrowing. Increased vascular permeability with plasma leakage is also a feature of asthma pathology and causes submucosal oedema. We hypothesize that, in asthmatics, the accumulation of enriched plasma in the environment surrounding airway smooth muscle promotes respiratory smooth muscle mitogenesis and hyperplasia. This situation represents the in vivo correlate of the increase in airway smooth muscle cell growth seen in vitro with increasing concentrations of serum in the culture medium. Thus, we hypothesize that vascular leakage in the airways in asthma is a primary pathogenic event leading to airway smooth muscle hyperplasia and hypertrophy, and consequently airway narrowing, promoting the characteristic bronchial hyperreactivity associated with narrowing of the airway lumen.
Keyword Reactivity
Invitro
Invivo
Cells
Responsiveness
Increases
Histamine
Dogs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Available online 20 December 2004.

Document type: Journal Article
Sub-type: Article
Collection: School of Biological Sciences Publications
 
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