Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity Disorder

Bellgrove, Mark A., Johnson, Katherine A., Barry, Edwina, Mulligan, Aisling, Hawi, Ziarah, Gill, Michael, Robertson, Ian and Chambers, Christopher D. (2009) Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity Disorder. Archives of General Psychiatry, 66 10: 1135-1142. doi:10.1001/archgenpsychiatry.2009.120

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Author Bellgrove, Mark A.
Johnson, Katherine A.
Barry, Edwina
Mulligan, Aisling
Hawi, Ziarah
Gill, Michael
Robertson, Ian
Chambers, Christopher D.
Title Dopaminergic Haplotype as a Predictor of Spatial Inattention in Children With Attention-Deficit/Hyperactivity Disorder
Journal name Archives of General Psychiatry   Check publisher's open access policy
ISSN 0003-990X
Publication date 2009-10
Year available 2009
Sub-type Article (original research)
DOI 10.1001/archgenpsychiatry.2009.120
Open Access Status File (Publisher version)
Volume 66
Issue 10
Start page 1135
End page 1142
Total pages 8
Place of publication Chicago, IL, United States
Publisher American Medical Association
Collection year 2010
Language eng
Formatted abstract
Context: A distinct pattern of selective attention deficits in attention-deficit/hyperactivity disorder (ADHD) has been difficult to identify. Heterogeneity may reflect differences in underlying genetics.

Objective: To document an objective deficit of selective attention in a large sample of children with and without ADHD using spatial orienting paradigms. By stratifying samples according to the gene dosage of a risk haplotype of the dopamine transporter gene (DAT1), we could determine whether genetic factors predict spatial
inattention in ADHD.

Design: A case-control design was used.

Setting: Children with ADHD were recruited from clinics or support groups in Ireland. Typically developing children were recruited from schools in and around Dublin, Ireland.

Participants: One hundred fifteen children were recruited (ADHD=50, control=65). Groups were matched for age but differed in estimated intelligence.

Intervention: Two versions of a visual spatial orienting task in which attention was directed by valid, neutral, or invalid cues to target locations. Sudden-onset peripheral cues (exogenous) and centrally presented predictive cues (endogenous) were used.

Main Outcome Measures:
To isolate an attention deficit in ADHD, groups were first compared using analysis of variance on the spatial orienting tasks. Multiple regression was used to assess the main effect of DAT1 haplotype status (heterozygous vs homozygous) and the interaction of diagnosis and genotype on those variables that discriminated children with and without ADHD.

Results: Children with ADHD displayed deficits in reorienting attention from invalidly cued spatial locations,particularly for targets in the left visual field. DAT1 haplotype status predicted spatial reorienting deficits for left visual field targets (P=.007) but there was also a significant interaction of diagnosis and genotype (P=.02), which revealed the greatest impairment in children with ADHD homozygous for the DAT1 haplotype.

Heterogeneity in selective attention in ADHD can be explained by a replicated genetic risk factor for ADHD, the 10/3 DAT1 haplotype.
Keyword Deficit-hyperactivity-disorder
Transporter gene
Selective attention
Hemispheric control
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Nov 2009, 12:05:15 EST by Mr Andrew Martlew on behalf of School of Psychology