Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Eeles, R. A., Kote-Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., Muir, K., Hopper, J. L., Henderson, B. E., Haiman, C. A., Schleutker, J., Hamdy, F. C., Neal, D. E., Donovan, J. L., Stanford, J. L., Ostrander, E. A., Ingles, S. A., John, E. M., Thibodeau, S. N., Schaid, D., Park, J. Y., Spurdle, A., Clements, J., Dickinson, J. L., Maier, C., Vogel, W., Dork, T., Rebbeck, T. R., Cooney, K. A., Cannon-Albright, L., Chappuis, P. O., Hutter, P., Zeegers, M., Kaneva, R., Zhang, H. W., Lu, Y. J., Foulkes, W. D., English, D. R., Leongamornlert, D. A., Tymrakiewicz, M., Morrison, J., Ardern-Jones, A. T., Hall, A. L., O'Brien, L. T., Wilkinson, R. A., Saunders, E. J., Page, E. C., Sawyer, E. J., Edwards, S. M., Dearnaley, D. P., Horwich, A., Huddart, R. A., Khoo, V. S., Parker, C. C., Van As, N., Woodhouse, C. J., Thompson, A., Christmas, T., Ogden, C., Cooper, C. S., Southey, M. C., Lophatananon, A., Liu, J. F., Kolonel, L. N., Le Marchand, L., Wahlfors, T., Tammela, T. L., Auvinen, A., Lewis, S. J., Cox, A., FitzGerald, L. M., Koopmeiners, J. S., Karyadi, D. M., Kwon, E. M., Stern, M. C., Corral, R., Joshi, A. D., Shahabi, A., McDonnell, S. K., Sellers, T. A., Pow-Sang, J., Chambers, S., Aitken, J., Gardiner, R. A., Batra, J., Kedda, M. A., Lose, F., Polanowski, A., Patterson, B., Serth, J., Meyer, A.., Luedeke, M, Stefflova, K., Ray, A. M., Lange, E. M., Farnham, J., Khan, H., Slavov, C., Mitkova, A., Cao, G. W. and Easton, D. F. (2009) Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41 10: 1116-1121. doi:10.1038/ng.450

Author Eeles, R. A.
Kote-Jarai, Z.
Al Olama, A. A.
Giles, G. G.
Guy, M.
Severi, G.
Muir, K.
Hopper, J. L.
Henderson, B. E.
Haiman, C. A.
Schleutker, J.
Hamdy, F. C.
Neal, D. E.
Donovan, J. L.
Stanford, J. L.
Ostrander, E. A.
Ingles, S. A.
John, E. M.
Thibodeau, S. N.
Schaid, D.
Park, J. Y.
Spurdle, A.
Clements, J.
Dickinson, J. L.
Maier, C.
Vogel, W.
Dork, T.
Rebbeck, T. R.
Cooney, K. A.
Cannon-Albright, L.
Chappuis, P. O.
Hutter, P.
Zeegers, M.
Kaneva, R.
Zhang, H. W.
Lu, Y. J.
Foulkes, W. D.
English, D. R.
Leongamornlert, D. A.
Tymrakiewicz, M.
Morrison, J.
Ardern-Jones, A. T.
Hall, A. L.
O'Brien, L. T.
Wilkinson, R. A.
Saunders, E. J.
Page, E. C.
Sawyer, E. J.
Edwards, S. M.
Dearnaley, D. P.
Horwich, A.
Huddart, R. A.
Khoo, V. S.
Parker, C. C.
Van As, N.
Woodhouse, C. J.
Thompson, A.
Christmas, T.
Ogden, C.
Cooper, C. S.
Southey, M. C.
Lophatananon, A.
Liu, J. F.
Kolonel, L. N.
Le Marchand, L.
Wahlfors, T.
Tammela, T. L.
Auvinen, A.
Lewis, S. J.
Cox, A.
FitzGerald, L. M.
Koopmeiners, J. S.
Karyadi, D. M.
Kwon, E. M.
Stern, M. C.
Corral, R.
Joshi, A. D.
Shahabi, A.
McDonnell, S. K.
Sellers, T. A.
Pow-Sang, J.
Chambers, S.
Aitken, J.
Gardiner, R. A.
Batra, J.
Kedda, M. A.
Lose, F.
Polanowski, A.
Patterson, B.
Serth, J.
Meyer, A..
Luedeke, M
Stefflova, K.
Ray, A. M.
Lange, E. M.
Farnham, J.
Khan, H.
Slavov, C.
Mitkova, A.
Cao, G. W.
Easton, D. F.
Title Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1038/ng.450
Volume 41
Issue 10
Start page 1116
End page 1121
Total pages 6
Place of publication New York, USA
Publisher Nature Publishing Group
Language eng
Subject 270200 Genetics
Formatted abstract
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 times 10-8 to P = 2.7 times 10-33).
Keyword Australian case-control
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 255 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Nov 2009, 12:00:49 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences