The fabrication and characterization of biodegradable HA/PHBV nanoparticle-polymer composite scaffolds

Jack, Kevin S., Velayudhan, Shiny, Luckman, Paul, Trau, Matt, Grondahl, Lisbeth and Cooper-White, Justin (2009) The fabrication and characterization of biodegradable HA/PHBV nanoparticle-polymer composite scaffolds. Acta Biomaterialia, 5 7: 2567-2667. doi:10.1016/j.actbio.2009.03.017


Author Jack, Kevin S.
Velayudhan, Shiny
Luckman, Paul
Trau, Matt
Grondahl, Lisbeth
Cooper-White, Justin
Title The fabrication and characterization of biodegradable HA/PHBV nanoparticle-polymer composite scaffolds
Journal name Acta Biomaterialia   Check publisher's open access policy
ISSN 1742-7061
Publication date 2009-09
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.actbio.2009.03.017
Volume 5
Issue 7
Start page 2567
End page 2667
Total pages 11
Editor W. Wagner
Place of publication Oxon, England
Publisher Elseiver Sci Ltd
Collection year 2010
Language eng
Subject C1
0903 Biomedical Engineering
970106 Expanding Knowledge in the Biological Sciences
Abstract This study reports the fabrication and characterization of nano-sized hydroxyapatite (HA)/poly(hydroxyabutyrate-co-hydroxyvalerate) (PHBV) polymer composite scaffolds with high porosity and controlled pore architectures. These scaffolds were prepared using a modified thermally induced phase-separation technique. This investigation focuses on the effect of fabrication conditions on the overall pore architecture of the scaffolds and the dispersion of HA nanocrystals within the composite scaffolds. The morphologies, mechanical properties and in vitro bioactivity of the composite scaffolds were investigated. It was noted that the pore architectures could be manipulated by varying phase-separation parameters. The HA particles were dispersed in the pore walls of the scaffolds and were well bonded to the polymer. The introduction of HA greatly increased the stiffness and strength, and improved the in vitro bioactivity of the scaffolds. The results suggest these newly developed nano-HA/PHBV composite scaffolds may serve as an effective three-dimensional substrate in bone tissue engineering. Crown Copyright (C) 2009 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.
Keyword Nano composite
Hydroxyapatite
Phase separation
Scaffold
In vitro mineralization
Bone Tissue Regeneration
In-Vitro
Nanofibrous Scaffolds
Poly(3-Hydroxybutyrate-CO-3-Hydroxyvalerate)
Hydroxyapatite
Osteoblast
Apatite
Poly(3-Hydroxybutyrate)
Crystallization
Proliferation
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Thu, 12 Nov 2009, 11:59:40 EST by Mr Andrew Martlew on behalf of Aust Institute for Bioengineering & Nanotechnology