The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy

Matucci-Cerinic, M., Allanore, Y., Czirjak, L., Tyndall, A., Muller-Ladner, U., Denton, C., Valentini, G., Distler, O., Fligelstone, K., Tyrrel-Kennedy, A., Farge, D., Kowal-Bielecka, O., van den Hoogen, F., Cutolo, M, Sampaio-Barros, PD, Nash, P., Takehara, K. and Furst, D. E. (2009) The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy. Annals of the Rheumatic Diseases, 68 9: 1377-1380. doi:10.1136/ard.2008.106302


Author Matucci-Cerinic, M.
Allanore, Y.
Czirjak, L.
Tyndall, A.
Muller-Ladner, U.
Denton, C.
Valentini, G.
Distler, O.
Fligelstone, K.
Tyrrel-Kennedy, A.
Farge, D.
Kowal-Bielecka, O.
van den Hoogen, F.
Cutolo, M
Sampaio-Barros, PD
Nash, P.
Takehara, K.
Furst, D. E.
Title The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 2009-09
Sub-type Article (original research)
DOI 10.1136/ard.2008.106302
Volume 68
Issue 9
Start page 1377
End page 1380
Total pages 4
Place of publication London, UK
Publisher British Medical Journal Publishing Group
Language eng
Subject 1103 Clinical Sciences
Abstract Early diagnosis of systemic sclerosis (SSc) may allow the start of treatment that could slow disease progression. For this reason early diagnosis of the disease is of pivotal importance. However, the lack of diagnostic criteria and valid predictors significantly limit patient evaluation and the use of potentially effective drugs in the earliest phase of SSc. Early SSc may be suspected on the basis of Raynaud's phenomenon, puffy fingers, autoantibodies and SSc capillaroscopic pattern. In practice, the aim is to have criteria for the diagnosis of very early SSc. The criteria that are proposed are obviously provisional and need to be validated: (a) initially through a Delphi technique; (b) thereafter perhaps using already available datasets; but (c) of critical importance, through prospective studies. Only after prospective studies can these potential criteria be considered validated. The consensus on criteria for the classification of very early SSc might be part of the evolving EULAR/ACR project of reclassification of SSc.
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 60 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 76 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 12 Nov 2009, 11:55:32 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences