Age and energy intake interact to modify cell stress pathways and stroke outcome

Thiruma V. Arumugam, Terry M. Phillips, Aiwu Cheng, Christopher H. Morrell, Mark P. Mattson and Ruiqian Wan (2009) Age and energy intake interact to modify cell stress pathways and stroke outcome. Annals of Neurology, 67 1: 41-52. doi:10.1002/ana.21798

Author Thiruma V. Arumugam
Terry M. Phillips
Aiwu Cheng
Christopher H. Morrell
Mark P. Mattson
Ruiqian Wan
Title Age and energy intake interact to modify cell stress pathways and stroke outcome
Journal name Annals of Neurology   Check publisher's open access policy
ISSN 0364-5134
Publication date 2009-07
Year available 2009
Sub-type Article (original research)
DOI 10.1002/ana.21798
Volume 67
Issue 1
Start page 41
End page 52
Total pages 12
Editor Stephen L Hauser
Adam F Stewart
Place of publication United States
Publisher John Wiley & Sons, Inc.
Collection year 2010
Language eng
Subject C1
920112 Neurodegenerative Disorders Related to Ageing
110904 Neurology and Neuromuscular Diseases
Abstract Age and excessive energy intake/obesity are risk factors for cerebrovascular disease, but it is not known if and how these factors affect the extent of brain damage and outcome in ischemic stroke. We therefore determined the interactions of age and energy intake on the outcome of ischemic brain injury, and elucidated the underlying mechanisms.We utilized a novel microchip-based immunoaffinity capillary electrophoresis technology to measure a panel of neurotrophic factors, cytokines and cellular stress resistance proteins in brain tissue samples from young, middle age and old mice that had been maintained on control or energy restricted diets prior to middle cerebral artery occlusion and reperfusion (I/R).Mortality from focal ischemic stroke was increased with advancing age and reduced by an intermittent fasting (IF) diet. Brain damage and functional impairment were reduced by IF in young and middle age mice, but not in old mice. The basal and post-stroke levels of neurotrophic factors (BDNF and bFGF), protein chaperones (HSP70 and GRP78) and the antioxidant enzyme HO-1 were decreased, while levels of inflammatory cytokines were increased in the cerebral cortex and striatum of old mice compared to younger mice. IF coordinately increased levels of protective proteins and decreases inflammatory cytokines in young, but not in old mice.Reduction in dietary energy intake differentially modulates neurotrophic and inflammatory pathways to protect neurons against ischemic injury, and these beneficial effects of IF are compromised during aging resulting in increased brain damage and poorer functional outcome. Ann Neurol 2009.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 09 Nov 2009, 12:42:56 EST by Cameron Harris on behalf of School of Biomedical Sciences