Involvement of Fc receptors in disorders of the Central Nervous System

Okun, Eitan, Mattson, Mark and Arumugam, Thiruma (2010) Involvement of Fc receptors in disorders of the Central Nervous System. NeuroMolecular Medicine, 12 2: 164-179. doi:10.1007/s12017-009-8099-5


Author Okun, Eitan
Mattson, Mark
Arumugam, Thiruma
Title Involvement of Fc receptors in disorders of the Central Nervous System
Journal name NeuroMolecular Medicine   Check publisher's open access policy
ISSN 1535-1084
1559-1174
Publication date 2010-06
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s12017-009-8099-5
Volume 12
Issue 2
Start page 164
End page 179
Total pages 15
Editor Mark Mattson
Place of publication United States
Publisher Human Press, Inc
Collection year 2010
Language eng
Subject C1
920111 Nervous System and Disorders
110903 Central Nervous System
Abstract Immunoglobulins are proteins with a highly variable antigen-binding domain and a constant region (Fc domain) that binds to a cell surface receptor (FcR). Activation of FcRs in immune cells (lymphocytes, macrophages, and mast cells) triggers effector responses including cytokine production, phagocytosis, and degranulation. In addition to their roles in normal responses to infection or tissue injury, and in immune-related diseases, FcRs are increasingly recognized for their involvement in neurological disorders. One or more FcRs are expressed in microglia, astrocytes, oligodendrocytes, and neurons. Aberrant activation of FcRs in such neural cells may contribute to the pathogenesis of major neurodegenerative conditions including Alzheimer’s disease, Parkinson’s disease, ischemic stroke, and multiple sclerosis. On the other hand, FcRs may play beneficial roles in counteracting pathological processes; for e.g., FcRs may facilitate removal of amyloid peptides from the brain and so protect against Alzheimer’s disease. Knowledge of the functions of FcRs in the nervous system in health and disease is leading to novel preventative and therapeutic strategies for stroke, Alzheimer’s disease, and other neurological disorders.
Keyword Fc receptors
Innate immunity
CNS
Neurons
Ischemic stroke
Alzheimer’s disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 09 Nov 2009, 10:58:52 EST by Cameron Harris on behalf of School of Biomedical Sciences