Internal standard - friend or foe?

Hewavitharana, Amitha (2009) Internal standard - friend or foe?. Critical Reviews in Analytical Chemistry, 39 4: 272-275. doi:10.1080/10408340903001201

Author Hewavitharana, Amitha
Title Internal standard - friend or foe?
Journal name Critical Reviews in Analytical Chemistry   Check publisher's open access policy
ISSN 0007-8980
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1080/10408340903001201
Volume 39
Issue 4
Start page 272
End page 275
Total pages 4
Editor Lochmuller, C.
Place of publication Philadelphia PA, USA
Publisher Taylor & Francis
Collection year 2010
Language eng
Subject C1
030301 Chemical Characterisation of Materials
970103 Expanding Knowledge in the Chemical Sciences
Abstract Internal standardization is a calibration technique that is commonly used to correct for procedural errors associated with quantitative analysis, thereby improving the accuracy of data. The commonly used protocol for internal standardization, presented through all analytical chemistry text books, relies upon a single point calibration for the compound that is used as the internal standard. Therefore, if the analyst is unaware of the linear range of the internal standard and uses a concentration that is outside the linear range, a severe loss of accuracy will occur. The severity is demonstrated through an example and precautions to prevent this problem are suggested. An alternative protocol for internal standardization that does not rely upon a single point calibration is also presented.
Keyword Internal Standard
Electro-spray MS
Ion Suppression
single-point calibration
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Fri, 06 Nov 2009, 15:47:49 EST by Charna Kovacevic on behalf of School of Pharmacy