Corticomotor excitability of back muscles is affected by intervertebral disc lesion in pigs

Hodges, Paul W., Galea, Mary P., Holm, Sten and Holm, Allison (2009) Corticomotor excitability of back muscles is affected by intervertebral disc lesion in pigs. European journal of neuroscience, 29 7: 1490-1500. doi:10.1111/j.1460-9568.2009.06670.x


Author Hodges, Paul W.
Galea, Mary P.
Holm, Sten
Holm, Allison
Title Corticomotor excitability of back muscles is affected by intervertebral disc lesion in pigs
Journal name European journal of neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2009-04
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2009.06670.x
Volume 29
Issue 7
Start page 1490
End page 1500
Total pages 11
Editor Jean-Marc Fritschy
Martin Sarter
Place of publication Oxford, U.K.
Publisher Wiley-Blackwell Publishing Ltd.
Collection year 2010
Language eng
Abstract Morphological and behavioural changes in back muscles are common in back pain and injury. Recent data indicate a rapid reduction in the size of the multifidus, a deep back muscle, within 3 days of experimental intervertebral disc (IVD) injury in pigs. A reduced neural drive may contribute to this. We investigated changes in corticomotor excitability following IVD lesion by evaluation of the response of back muscles to electrical stimulation of the motor cortex. Motor evoked potentials (MEPs) were studied in 12 Swedish landrace pigs before injury, immediately after abdominal incision, immediately after L3-4 IVD lesion with a scalpel, and 15 min later. In two animals, responses were also evoked by descending volleys excited at the level of the mastoid processes (cervicomedullary evoked potentials) without motor cortex activation. In five animals, a sham procedure was followed without IVD lesion. MEPs were recorded in short (deep) and long (superficial) fibres of the multifidus at L3-5 on the lesioned side and at L4 contralaterally with intramuscular wire electrodes. Although the MEP amplitude increased in several muscles after incision, at 15 min after IVD lesion only the MEP amplitude of the deep L4 multifidus on the lesioned side was increased [36% (SD 15%), P < 0.05]. There were no changes in MEP amplitude after 15 min at adjacent or contralateral levels. The response to cervicomedullary stimulation reduced slightly. This suggests that the increased MEP amplitude was due to changes in cortical excitability. These data indicate that IVD lesion induces localized increases, and not decreases, in the excitability of cortical inputs to the deep paraspinal muscles that cross a lesioned disc.
Keyword Injury
Motor evoked potential
Multifidus
Pain
Reflex inhibition
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 03 Nov 2009, 12:15:43 EST by Carmen Buttery on behalf of School of Health & Rehabilitation Sciences