Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis

Baumann, Fusan, Henderson, Robert D., Morrison, Stephen C., Brown, Michael, Hutchinson, N., Douglas, James A., Robinson, Peter J. and McCombe, Pamela A. (2010) Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis, 11 1-2: 194-202. doi:10.3109/17482960902991773


Author Baumann, Fusan
Henderson, Robert D.
Morrison, Stephen C.
Brown, Michael
Hutchinson, N.
Douglas, James A.
Robinson, Peter J.
McCombe, Pamela A.
Title Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis
Journal name Amyotrophic Lateral Sclerosis   Check publisher's open access policy
ISSN 1748-2968
1471-180X
Publication date 2010
Sub-type Article (original research)
DOI 10.3109/17482960902991773
Volume 11
Issue 1-2
Start page 194
End page 202
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2011
Language eng
Formatted abstract
Respiratory function tests (RFTs) are commonly used as a measure of progression in ALS. This study assessed the ability of various RFTs to predict survival in ALS patients. Subjects with ALS had one or more measurements of seated and supine FVC, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP). Kaplan-Meier (KM) analysis was used to determine whether patients with abnormal RFTs had shorter survival than those with normal RFTs. The sensitivity and specificity of RFTs as predictors of two-year survival were calculated from receiver operating characteristic (ROC) curves. With KM analysis, subjects with abnormal values of seated FVC, supine FVC, MIP and MEP had significantly reduced survival compared to subjects with normal values. With ROC curves, a normal supine FVC was highly predictive for two-year survival and had superior sensitivity over seated FVC. Slower rates of decline in seated or supine FVC were strong predictors of two-year survival. Our study demonstrates that respiratory function measurements are useful to predict survival in ALS patients. We show that measurements of FVC in the supine position are worth including in the assessment of respiratory function in ALS.
© 2010 Informa UK Ltd.
Keyword Amyotrophic lateral sclerosis
Respiratory function tests
Prognostic
Biomarkers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 12 Oct 2009, 12:50:40 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research