Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies

Morris, Melissa S., Yeonju, Lee, Lavin, Mark T., Giannini, Peter J., Schmid, Marian J., Marx, David B. and Reinhardt, Richard A. (2008) Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies. Journal of Periodontology, 79 8: 1465-1473. doi:10.1902/jop.2008.070659


Author Morris, Melissa S.
Yeonju, Lee
Lavin, Mark T.
Giannini, Peter J.
Schmid, Marian J.
Marx, David B.
Reinhardt, Richard A.
Title Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies
Journal name Journal of Periodontology   Check publisher's open access policy
ISSN 0022-3492
Publication date 2008-08
Year available 2009
Sub-type Article (original research)
DOI 10.1902/jop.2008.070659
Volume 79
Issue 8
Start page 1465
End page 1473
Total pages 8
Editor Kenneth S. Kornman
Julie Daw
Place of publication United States
Publisher American Academy of Periodontology
Language eng
Formatted abstract
Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects.

Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis.

Results:
Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P = 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P = 0.069). No new cementum was found in furcations.

Conclusions:
Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.
Keyword Bone regeneration
cementum
drug delivery
histology
wound healing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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Created: Wed, 07 Oct 2009, 15:58:03 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research