Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein

Fang Z. M., Tse R. V., Marjoniemi V. M., Koslov, S., Lavin, M. F., Chen, H., Kearsley, J. H., Graham, P. H. and Clarke, R. A. (2009) Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein. Journal of Medical Imaging and Radiation Oncology, 53 2: 234-239. doi:10.1111/j.1754-9485.2009.02053.x


Author Fang Z. M.
Tse R. V.
Marjoniemi V. M.
Koslov, S.
Lavin, M. F.
Chen, H.
Kearsley, J. H.
Graham, P. H.
Clarke, R. A.
Title Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1754-9485.2009.02053.x
Volume 53
Issue 2
Start page 234
End page 239
Total pages 6
Editor David Ball
Place of publication Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2010
Language eng
Subject C1
1103 Clinical Sciences
1007 Nanotechnology
Abstract Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.
Keyword ataxia telangiectasia mutated protein level
breast cancer
malignant myoepithelioma
p53 mutation
radioresistance
radiotherapy
tumour cell line
Q-Index Code C1
Q-Index Status Provisional Code
Additional Notes Published Online: 26 May 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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Created: Thu, 08 Oct 2009, 00:52:37 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research