Developing a drug-like natural product library

Quinn, Ronald J., Carroll, Anthony R., Pham, Ngoc B., Baron, Paul, Palframan, Meredith E., Suraweera, Lekha., Pierens, Gregory K. and Muresan, Sorel. (2008) Developing a drug-like natural product library. Journal of Natural Products, 71 3: 464-468. doi:10.1021/np070526y


Author Quinn, Ronald J.
Carroll, Anthony R.
Pham, Ngoc B.
Baron, Paul
Palframan, Meredith E.
Suraweera, Lekha.
Pierens, Gregory K.
Muresan, Sorel.
Title Developing a drug-like natural product library
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2008-03
Sub-type Article (original research)
DOI 10.1021/np070526y
Volume 71
Issue 3
Start page 464
End page 468
Total pages 5
Place of publication United States
Publisher American Chemical Society
Collection year 2009
Language eng
Subject 03 Chemical Sciences
0305 Organic Chemistry
Abstract Addressing drug-like/lead-like properties of biologically active small molecules early in a lead generation program is the current paradigm within the drug discovery community. Lipinski’s “rule of five” has become the most commonly used tool to assess the relationship between structures and drug-like properties. Sixty percent of the 126140 unique compounds in The Dictionary of Natural Products had no violations of Lipinski’s “rule of five”. We have isolated 814 natural products based on their expected drug-like/lead-like properties to generate a natural product library (NPL) in which 85% of the isolated compounds had no Lipinski violations. The library demonstrates the feasibility of obtaining natural products known for rich chemical diversity with the required physicochemical properties for drug discovery. The knowledge generated in creation of the library of structurally characterized pure natural products may provide opportunities to front-load lead-like property space in natural product drug discovery programs. Copyright © 2008 The American Chemical Society and American Society of Pharmacognosy
Keyword Lead generation
Drug development
Natural products
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Unknown
Additional Notes Erratum: Journal of Natural Products Volume 71, Issue 10, October 2008, Page 1792

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
ERA 2012 Admin Only
Centre for Advanced Imaging Publications
 
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Created: Thu, 01 Oct 2009, 12:44:49 EST by Therese Egan on behalf of School of Biomedical Sciences