The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor

Camarda, Grazia, Spinetti, Gaia, Bernardini, Giovanni, Mair, Catherine, Davis-Poynter, Nick, Capogrossi, Maurizio C. and Napolitano, Monica (1999) The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor. Journal of Virology, 73 12: 9843-9848.

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Author Camarda, Grazia
Spinetti, Gaia
Bernardini, Giovanni
Mair, Catherine
Davis-Poynter, Nick
Capogrossi, Maurizio C.
Napolitano, Monica
Title The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 1999-12
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 73
Issue 12
Start page 9843
End page 9848
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 060506 Virology
0707 Veterinary Sciences
0601 Biochemistry and Cell Biology
Abstract Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr virus. The E1 ORF of EHV-2, a G protein-coupled receptor homolog, shows 31 to 47% amino acid identity with known CC chemokine receptors. To investigate whether E1 may encode a functional receptor, we cloned the E1 ORF and expressed it in stably transfected cell lines. We report here the identification of the CC chemokine eotaxin as a functional ligand for the EHV-2 E1 receptor. Chemokines are likely to play a role in the regulation of immune functions in equine hosts during EHV-2 infection and, via interaction with E1, may affect viral replication and/or escape from immune responses.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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