Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats

Moritz, K. M., Mazzuca, M. Q., Siebel, A. L., Mibus, A., Arena, D., Tare, M., Owens, J. A. and Wlodek, M. E. (2009) Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats. Journal of Physiology, 587 11: 2635-2646. doi:10.1113/jphysiol.2009.170407


Author Moritz, K. M.
Mazzuca, M. Q.
Siebel, A. L.
Mibus, A.
Arena, D.
Tare, M.
Owens, J. A.
Wlodek, M. E.
Title Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats
Journal name Journal of Physiology   Check publisher's open access policy
ISSN 0022-3751
Publication date 2009-04
Year available 2009
Sub-type Article (original research)
DOI 10.1113/jphysiol.2009.170407
Volume 587
Issue 11
Start page 2635
End page 2646
Total pages 12
Editor William A Large
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Collection year 2010
Language eng
Subject C1
920501 Child Health
111603 Systems Physiology
110201 Cardiology (incl. Cardiovascular Diseases)
110312 Nephrology and Urology
1401 Economic Theory
Abstract In rats, uteroplacental insufficiency induced by uterine vessel ligation restricts fetal growth and impairs mammary development compromising postnatal growth. In male offspring, this results in a nephron deficit and hypertension which can be reversed by improving lactation and postnatal growth. Here, growth, blood pressure and nephron endowment in female offspring from mothers which underwent bilateral uterine vessel ligation (Restricted) on day 18 of pregnancy were examined. Sham surgery (Control) and a reduced litter group (Reduced at birth to 5, equivalent to Restricted group) were used as controls. Offspring (Control, Reduced, Restricted) were cross-fostered on postnatal day 1 onto a Control (normal lactation) or Restricted (impaired lactation) mother. Restricted-on-Restricted offspring were born small but were of similar weight to Control-on-Control by postnatal day 35. Blood pressure was not different between groups at 8, 12 or 20 weeks of age. Glomerular number was reduced in Restricted-on-Restricted offspring at 6 months without glomerular hypertrophy. Cross-fostering a Restricted pup onto a Control dam resulted in a glomerular number intermediate between Control-on-Control and Restricted-on-Restricted. Blood pressure, along with renal function, morphology and mRNA expression, was examined in Control-on-Control and Restricted-on-Restricted females at 18 months. Restricted-on-Restricted offspring did not become hypertensive but developed glomerular hypertrophy by 18 months. They had elevated plasma creatinine and alterations in renal mRNA expression of transforming growth factor-beta(1), collagen IV (alpha 1) and matrix matelloproteinase-9. This suggests that perinatally growth restricted female offspring may be susceptible to onset of renal injury and renal insufficiency with ageing in the absence of concomitant hypertension.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 61 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 68 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 10 Sep 2009, 14:55:37 EST by Cameron Harris on behalf of School of Biomedical Sciences