Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study

Reid, Alastair G., Daglish, Mark R. C., Kempton, Matthew J., Williams, Tim M., Watson, Ben and Lingford-Hughes, Anne R. (2008) Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study. Journal of psychopharmacology, 22 1: 7-10. doi:10.1177/0269881107080795


Author Reid, Alastair G.
Daglish, Mark R. C.
Kempton, Matthew J.
Williams, Tim M.
Watson, Ben
Lingford-Hughes, Anne R.
Title Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study
Journal name Journal of psychopharmacology   Check publisher's open access policy
ISSN 0269-8811
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1177/0269881107080795
Volume 22
Issue 1
Start page 7
End page 10
Total pages 4
Place of publication United Kingdom
Publisher British Association for Psychopharmacology
Language eng
Subject 11 Medical and Health Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract The aim of this study was to make a comparison of brain structure between a group of opioid-dependent subjects and healthy controls. We report the results of an ‘optimized’ voxel-based morphometry study on a sample of nine opioid-dependent subjects with no comorbid substance misuse disorders versus 21 healthy controls. We found a significant reduction in grey matter volume of the thalamus after controlling for age and total grey matter volume. Regression analysis of substance use variables in the opioid-dependent sample shows that only level of alcohol use negatively predicts grey matter volume for this region of difference. We suggest that level of nondependent alcohol use could influence reduced thalamic grey matter volume in opioid-dependent subjects.
Keyword Opioid-dependence
Opioid addiction
Neuroimaging
MRI
VBM
Voxel-based morphometry
Alcohol
Thalamus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 09 Sep 2009, 21:52:31 EST by Therese Egan on behalf of School of Medicine