Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity

Pai, Saparna and Thomas, Ranjeny (2008) Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity. Journal of Autoimmunity, 31 3: 245-251. doi:10.1016/j.jaut.2008.04.012


Author Pai, Saparna
Thomas, Ranjeny
Title Immune deficiency or hyperactivity-Nf-κb illuminates autoimmunity
Journal name Journal of Autoimmunity   Check publisher's open access policy
ISSN 0896-8411
1095-9157
Publication date 2008-11
Sub-type Article (original research)
DOI 10.1016/j.jaut.2008.04.012
Volume 31
Issue 3
Start page 245
End page 251
Total pages 7
Editor A. Richard Kitching
Place of publication Camden, London, U.K.
Publisher Academic Press
Language eng
Subject 1107 Immunology
Abstract Nuclear factor (NF)-κB is a transcription factor family which transmits signals from the cell surface to the nucleus, resulting in transcriptional effects on genes involved in inflammation, cell differentiation and survival. The signaling of NF-κB and mitogen-activated protein (MAP) kinases through adapter molecules is of critical importance to survival and activation of all cells in the body, including those regulating innate and adaptive immunity. Here we review the individual and intersecting roles played by the alternate and classical NF-κB pathways in the pathogenesis of autoimmune disease. Understanding the differences in classical and alternate NF-κB function has greatly assisted the development of models of their contribution to different autoimmune diseases. To exemplify these concepts, we consider the contribution of NF-κB to rheumatoid arthritis and type 1 diabetes pathogenesis and approaches to immunotherapy. Copyright © 2009 Elsevier Ltd. All rights reserved
Keyword NF-kappa B
Tolerance
Autoimmunity
Type 1 diabetes
Rheumatoid arthritis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Issue title: Mechanisms of Autoimmunity: A Tribute to Professor Ian Mackay. A selection of papers presented at the 11th Australasian Autoimmunity Workshop

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
UQ Diamantina Institute Publications
 
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Created: Tue, 08 Sep 2009, 11:53:35 EST by Therese Egan on behalf of UQ Diamantina Institute