Local dynamic changes in confined extracellular environments within organs

Behrendorff, Natasha, Shukla, Alka, Schwiening, Christof and Thorn, Peter (2009) Local dynamic changes in confined extracellular environments within organs. Clinical and Experimental Pharmacology and Physiology, 36 10: 1010-1015. doi:10.1111/j.1440-1681.2009.05205.x

Author Behrendorff, Natasha
Shukla, Alka
Schwiening, Christof
Thorn, Peter
Title Local dynamic changes in confined extracellular environments within organs
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.2009.05205.x
Volume 36
Issue 10
Start page 1010
End page 1015
Total pages 6
Editor Paul Bertand
Ding-Feng Su
Roger Evans
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060602 Animal Physiology - Cell
060111 Signal Transduction
110307 Gastroenterology and Hepatology
111601 Cell Physiology
Abstract 1. Herein we review past work that has studied the composition of luminal fluid in organs, with a focus on measures of calcium and pH in the exocrine glands. This luminal environment is 'external' to the mammalian body and is not subject to the usual mechanisms of homeostatic control. Instead, it is controlled by the behaviour of the cells that line the lumen. 2. We discuss the likely possibility that rapid and local changes in calcium and pH occur within microdomains in the lumen. Further, we present preliminary evidence, using live cell imaging of intact pancreatic fragments, that supports the idea that pH changes do occur. Our evidence indicates that exocytosis of secretory granules in pancreatic acinar cells leads to a loss of protons from the granule and a subsequent local acidification of the lumen. 3. These changes in luminal composition are placed in the context of diseases of the pancreas, such as cystic fibrosis and pancreatitis, both of which are known to result in perturbations of luminal fluid composition.
Keyword Calcium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Presented at the AuPS Symposium: Epithelial Cell Biology, Melbourne, November/December 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 04 Sep 2009, 14:56:56 EST by Cameron Harris on behalf of School of Biomedical Sciences