Is Mycophenolate more than just an Immunosuppressant? - An Overview

Iyer, A. and Brown, L. (2009) Is Mycophenolate more than just an Immunosuppressant? - An Overview. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 46 1: 25-30.

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Author Iyer, A.
Brown, L.
Title Is Mycophenolate more than just an Immunosuppressant? - An Overview
Journal name INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS   Check publisher's open access policy
ISSN 0301-1208
Publication date 2009-02
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
Open Access Status File (Publisher version)
Volume 46
Issue 1
Start page 25
End page 30
Total pages 6
Place of publication India
Publisher Council of Scientific and Industrial Research
Collection year 2010
Language eng
Subject C1
920103 Cardiovascular System and Diseases
111501 Basic Pharmacology
Abstract The development of The development of immunosuppressant compounds such cyclosporine and tacrolimus was crucial to the success of transplant surgery and for treatment of autoimmune diseases. However, immunosuppressant therapy may increase the concentrations of reactive oxygen species (ROS), inducing oxidative damage such as an increased vascular damage. The major source of ROS in the vascular endothelial cells is NADPH oxidase. The subunit structure and function of this enzyme complex in vascular cells differs from than in phagocytic leucocytes. The enzyme subunits Nox1 and Nox2 and Nox4 are only found in vascular cells. The GTP-dependent protein subunit Rac 1 needs to be activated for this enzyme to function. Inhibiting this protein subunit should reduce NADPH oxidase-induced oxidative stress. In this cardiovascular systsem, oxidative stress is observed as hypertension, hypertrophy, fibrosis, conduction abnormalities and endothelial dysfunction, as well as caridac allograft vasculopathy in transplant patients. In contrast to cyclosporine and tacrolimus, the immunosuppresant mycophenolate inhibits the Rac 1 subunit thus inhibiting NADPH oxidase in the vasculature. This may reduce oxidative stress, prevent the development of cardiac allograft vasculopathy, decrease the deterioration of vascular function and improve cardiovascular function chronically in transplant patients. This overview discusses whether this anti-oxidant immunosuppressive property could translate into a more general protective role for mycophenolate in the prevention of cardiovascular disease.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
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Created: Fri, 04 Sep 2009, 11:52:35 EST by Cameron Harris on behalf of School of Biomedical Sciences