Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease

Almeida, Osvaldo P., Garrido, Griselda J., Lautenschlager, Nicola T., Hulse, Gary K., Jamrozik, Konrad and Flicker, Leon (2008) Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease. American Journal of Geriatric Psychiatry, 16 1: 92-98. doi:10.1097/JGP.0b013e318157cad2


Author Almeida, Osvaldo P.
Garrido, Griselda J.
Lautenschlager, Nicola T.
Hulse, Gary K.
Jamrozik, Konrad
Flicker, Leon
Title Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease
Journal name American Journal of Geriatric Psychiatry   Check publisher's open access policy
ISSN 1064-7481
Publication date 2008-01
Sub-type Article (original research)
DOI 10.1097/JGP.0b013e318157cad2
Volume 16
Issue 1
Start page 92
End page 98
Total pages 7
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
The results of observational studies suggest that smoking increases the risk of Alzheimer disease (AD). The authors designed this study to determine if older people who smoke have decreased gray matter density in brain regions associated with incipient AD. Methods: The authors recruited 39 pairs (N=78) of smokers/never-smokers 70 to 83 years of age who were matched for age, sex, education, and handedness. Participants were free of clinically significant cognitive impairment, depression, stroke, or other serious medical conditions. Gray matter density was determined by voxel-based morphometry using statistical parametric mapping of T1-weighted magnetic resonance images. Results: Smokers had decreased gray matter density in the posterior cingulum and precuneus (bilateral), right thalamus, and frontal cortex (bilateral) compared with never-smokers. Conclusions: Smoking is associated with decreased gray matter density in brain regions previously associated with incipient AD. Longitudinal investigations are required to clarify whether these changes are progressive in nature. (Am J Geriatr Psychiatry 2008; 16:92–98)
Keyword Statistical parametric mapping
Voxel-based Morphometry
Smoking
Tobacco
Alzheimer disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Thu, 03 Sep 2009, 10:36:10 EST by Mr Andrew Martlew on behalf of School of Public Health