A bacterial metapopulation adapts locally to phage predation despite global dispersal

Kunin, V., He, S., Warnecke, F., Peterson, S. B., Martin, H. G., Haynes, M., Ivanova, N., Blackall, L. L., Breitbart, M., Rohwer, F., McMahon, K. D. and Hugenholtz, P. (2008) A bacterial metapopulation adapts locally to phage predation despite global dispersal. Genome Research, 18 2: 293-297. doi:10.1101/gr.6835308

Author Kunin, V.
He, S.
Warnecke, F.
Peterson, S. B.
Martin, H. G.
Haynes, M.
Ivanova, N.
Blackall, L. L.
Breitbart, M.
Rohwer, F.
McMahon, K. D.
Hugenholtz, P.
Title A bacterial metapopulation adapts locally to phage predation despite global dispersal
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1101/gr.6835308
Open Access Status DOI
Volume 18
Issue 2
Start page 293
End page 297
Total pages 5
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Language eng
Formatted abstract
Using a combination of bacterial and phage-targeted metagenomics, we analyzed two geographically remote sludge bioreactors enriched in a single bacterial species Candidatus Accumulibacter phosphatis (CAP). We inferred unrestricted global movement of this species and identified aquatic ecosystems as the primary environmental reservoirs facilitating dispersal. Highly related and geographically remote CAP strains differed principally in genomic regions encoding phage defense mechanisms. We found that CAP populations were high density, clonal, and nonrecombining, providing natural targets for "kill-the-winner" phage predation. Community expression analysis demonstrated that phages were consistently active in the bioreactor community. Genomic signatures linking CAP to past phage exposures were observed mostly between local phage and host. We conclude that CAP strains disperse globally but must adapt to phage predation pressure locally.
©2008 by Cold Spring Harbor Laboratory Press.
Keyword Biological phosphorus removal
Community structure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 83 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 10:30:38 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences