Body size and risk of epithelial ovarian and related cancers: A population-based case-control study

Olsen, Catherine M., Nagle, Christina M., Whiteman, David C., Purdie, David M., Green, Adèle C. and Webb, Penelope M. (2008) Body size and risk of epithelial ovarian and related cancers: A population-based case-control study. International Journal of Cancer, 123 2: 450-456. doi:10.1002/ijc.23509


Author Olsen, Catherine M.
Nagle, Christina M.
Whiteman, David C.
Purdie, David M.
Green, Adèle C.
Webb, Penelope M.
Title Body size and risk of epithelial ovarian and related cancers: A population-based case-control study
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
0020-7136
Publication date 2008-07
Sub-type Article (original research)
DOI 10.1002/ijc.23509
Volume 123
Issue 2
Start page 450
End page 456
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 1112 Oncology and Carcinogenesis
Abstract Different subtypes of ovarian cancer appear to have different causes; however, the association between body mass index (BMI) and the different subtypes is unclear. We examined the associations between body-mass index (BMI) and weight gain and risk of the different histological subtypes of epithelial ovarian cancer in a case-control study in Australia. Cases aged 18-79 with a new diagnosis of invasive epithelial ovarian cancer (n = 1,269) or borderline tumor (n = 311) were identified through a network of clinics and cancer registries throughout Australia. Controls (n = 1,509) were selected from the Electoral Roll. Height and weight (1 year previously, at age 20 and maximum weight) and other risk factor information were ascertained via a self-administered questionnaire. Obesity was positively associated with clear cell tumors (Odds Ratio 2.3; 95% confidence interval 1.2-4.2) but not invasive endometrioid or mucinous tumors. Although there was no association with invasive serous tumors overall (0.9; 0.7-1.2), we did see an increased risk of serous peritoneal tumors (2.9; 1.7-4.9), but not of serous tumors of the ovary and fallopian tube. Of the borderline subtypes, obesity was positively associated with serous (1.8; 1.1-2.8) but not mucinous tumors (1.1; 0.7-1.7). Overweight was not associated with any subtype overall. There was no association with BMI at age 20, or weight gain for any of the histological subtypes. These results add to the current evidence that obesity increases a woman's risk of developing distinct histological subtypes of ovarian cancer.
Keyword Ovarian cancer
Obesity
Body weight
Body mass index
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Thu, 03 Sep 2009, 09:55:46 EST by Mr Andrew Martlew on behalf of School of Public Health