The case for transgenerational epigenetic inheritance in humans

Morgan, Daniel K. and Whitelaw, Emma (2008) The case for transgenerational epigenetic inheritance in humans. Mammalian Genome, 19 6: 394-397. doi:10.1007/s00335-008-9124-y


Author Morgan, Daniel K.
Whitelaw, Emma
Title The case for transgenerational epigenetic inheritance in humans
Journal name Mammalian Genome   Check publisher's open access policy
ISSN 0938-8990
1432-1777
Publication date 2008-06
Sub-type Article (original research)
DOI 10.1007/s00335-008-9124-y
Volume 19
Issue 6
Start page 394
End page 397
Total pages 4
Place of publication New York, USA
Publisher Springer
Language eng
Subject 0604 Genetics
Abstract Work in the laboratory mouse has identified a group of genes, called metastable epialleles, that are informing us about the mechanisms by which the epigenetic state is established in the embryo. At these alleles, transcriptional activity is dependent on the epigenetic state and this can vary from cell to cell in the one tissue type. The decision to be active or inactive is probabilistic and sensitive to environmental influences. Moreover, in some cases the epigenetic state at these alleles can survive across generations, termed transgenerational epigenetic inheritance. Together these findings raise the spectre of Lamarckism and epigenetics is now being touted as an explanation for some intergenerational effects in human populations. In this review we will discuss the evidence so far.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 09:29:31 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences