Utility of a patient survey in identifying fluctuations in early stage Parkinson's disease

Silburn, P. A., Mellick, G. D., Vieira, B. I., Danta, G., Boyle, R. S. and Herawati, L. (2008) Utility of a patient survey in identifying fluctuations in early stage Parkinson's disease. Journal of Clinical Neuroscience, 15 11: 1235-1239. doi:10.1016/j.jocn.2007.09.018

Author Silburn, P. A.
Mellick, G. D.
Vieira, B. I.
Danta, G.
Boyle, R. S.
Herawati, L.
Title Utility of a patient survey in identifying fluctuations in early stage Parkinson's disease
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
Publication date 2008-11
Sub-type Article (original research)
DOI 10.1016/j.jocn.2007.09.018
Volume 15
Issue 11
Start page 1235
End page 1239
Total pages 4
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Language eng
Subject 1103 Clinical Sciences
Abstract Motor and non-motor fluctuations are well known sequelae of dopaminergic therapies for Parkinson’s disease (PD), particularly during the advanced stages. However, the prevalence of fluctuations early in the treatment course has been less well recognised and may be missed clinically if not specifically probed. We examined the used of a survey for this purpose. Patients to be surveyed were recruited by neurologists and geriatricians at 20 Australian centres. Patients had a diagnosis of idiopathic PD with a duration of fewer than 5 years and were considered by their treating physician to be non-fluctuating or had no change in their treatment plan in the prior 6 months. Patients, with or without assistance, completed a 19-item wearing-off questionnaire to assess the presence of motor and non-motor fluctuations that indicated early wearing-off. Investigators assessed the usefulness of the questionnaire in detecting fluctuations and guiding PD treatment. Of 105 patients recruited, 92 were eligible for analysis. There were 56 (61%) identified as having fluctuations. Patients with wearing-off were younger (mean 67 vs 72 years), and more likely to have had PD for more than 3 years. About half the patients (49%) were able to complete the questionnaire independently. Clinicians perceived the questionnaire as useful for detecting fluctuations and adjusting treatment. A simple and easily administered wearing-off questionnaire may be useful in the early detection of fluctuations in PD patients and assist in guiding therapy.
Keyword Parkinson’s disease
Motor fluctuations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
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Created: Thu, 03 Sep 2009, 09:17:24 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences