Current and future approach to the pathologist's assessment for targeted therapy in breast cancer

Pakkiri, P, Lakhani, SR and Smart, CE (2009) Current and future approach to the pathologist's assessment for targeted therapy in breast cancer. Pathology, 41 1: 89-99. doi:10.1080/00313020802563551


Author Pakkiri, P
Lakhani, SR
Smart, CE
Title Current and future approach to the pathologist's assessment for targeted therapy in breast cancer
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 2009-01
Year available 2009
Sub-type Article (original research)
DOI 10.1080/00313020802563551
Volume 41
Issue 1
Start page 89
End page 99
Total pages 11
Editor C.S. Lee
Place of publication Colchester, Essex, U.K.
Publisher Taylor & Francis Ltd.
Collection year 2010
Language eng
Subject C1
110316 Pathology (excl. Oral Pathology)
920102 Cancer and Related Disorders
Abstract Breast cancer is a common disease in the population. Contrary to public perception, it is a heterogeneous disease with varying morphology, prognosis and response to therapy. The pathological analysis is at the heart of information provided to surgeons and oncologists to plan further management. The pathologist is increasingly asked to test for biomarkers that provide prognostic and predictive information to direct treatment. Staining cancers for ER, PgR and HER2 has become routine and it is likely that addition of other biomarkers including 'basal markers', VEGF and growth factor receptors such as HER1 (EGFR) will soon follow. Microarray based genomic, transcription and proteomic methods are changing our classification systems and identifying novel targets for the development of new therapeutics. It is important for pathologists to appreciate and embrace the new developments as they will impact on daily clinical practice and require accurate assessment of biomarkers to determine treatment options as part of multidisciplinary teams.
Keyword Breast cancer
targeted therapy
Pathology
Biomarkers
Prognosis
E
HER2
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 09:07:44 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research