Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community

Mehta, Prachi, Mellick, George D., Rowe, Dominic B., Halliday, Glenda M., Jones, Michael M., Manwaring, Neil, Vandebona, Himesha, Silburn, Peter A., Wang, Jie Jin, Mitchell, Paul and Sue, Carolyn M. (2009) Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community. Movement Disorders, 24 2: 290-292. doi:10.1002/mds.22389


Author Mehta, Prachi
Mellick, George D.
Rowe, Dominic B.
Halliday, Glenda M.
Jones, Michael M.
Manwaring, Neil
Vandebona, Himesha
Silburn, Peter A.
Wang, Jie Jin
Mitchell, Paul
Sue, Carolyn M.
Title Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
1531-8257
Publication date 2009-01
Sub-type Article (original research)
DOI 10.1002/mds.22389
Volume 24
Issue 2
Start page 290
End page 292
Total pages 3
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/ RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.
Keyword Parkinson's disease
Mitochondrial DNA
Haplogroups
Prevalence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 08:48:45 EST by Mr Andrew Martlew on behalf of School of Medicine