Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

Dissanayaka, Nadeeka N. W., Silburn, Peter A., O'Sullivan, John D. and Mellick, George D. (2009) Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease. Movement Disorders, 24 1: 111-115. doi:10.1002/mds.22134


Author Dissanayaka, Nadeeka N. W.
Silburn, Peter A.
O'Sullivan, John D.
Mellick, George D.
Title Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
1531-8257
Publication date 2009-01-15
Year available 2008
Sub-type Article (original research)
DOI 10.1002/mds.22134
Volume 24
Issue 1
Start page 111
End page 115
Total pages 5
Editor Christopher G. Goetz
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Language eng
Subject C1
1103 Clinical Sciences
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Formatted abstract
Altered levels of the neurotransmitters dopamine and serotonin are observed in both Parkinson's disease (PD) and depression. Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. We genotyped 24 tagging SNPs together with VNTRs and the SLC6A4 LPR polymorphism in 190 PD patients categorised according to lifetime history of depression. Log-additive, dominant and recessive statistical models were constructed. No significant genotype or haplotype associations were observed suggesting that common genetic variables around the dopamine and serotonin transporter genes do not play a significant role in the etiology of depression in PD.
Keyword Allelic variation
SLC6A4
SLC6A3
Depression
Parkinson’s disease
Haplotypes
Genetic variants
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article first published online: 30 OCT 2008. Published under "Brief Reports".

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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Created: Thu, 03 Sep 2009, 08:48:40 EST by Mr Andrew Martlew on behalf of Medicine - Royal Brisbane and Women's Hospital