Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates

Krauland, Mary G., Marsh, Jane W., Paterson, David L. and Harrison, Lee H. (2009) Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates. Emerging Infectious Diseases, 15 3: 388-396. doi:10.3201/eid1503.081131


Author Krauland, Mary G.
Marsh, Jane W.
Paterson, David L.
Harrison, Lee H.
Title Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates
Journal name Emerging Infectious Diseases   Check publisher's open access policy
ISSN 1080-6040
Publication date 2009-03
Year available 2009
Sub-type Article (original research)
DOI 10.3201/eid1503.081131
Open Access Status DOI
Volume 15
Issue 3
Start page 388
End page 396
Total pages 9
Editor D Peter Drotman
Place of publication Atlanta, GA, United States of America
Publisher U.S Department of Health and Human Services, Centres for Disease Control and Prevention
Collection year 2010
Language eng
Subject C1
920109 Infectious Diseases
110309 Infectious Diseases
Abstract Salmonella enterica bacteria have become increasingly resistant to antimicrobial agents, partly as a result of genes carried on integrons. Clonal expansion and horizontal gene transfer may contribute to the spread of antimicrobial drug-resistance integrons in these organisms. We investigated this resistance and integron carriage among 90 isolates with the ACSSuT phenotype (resistance to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline) in a global collection of S. enterica isolates. Four integrons, dfrA12/orfF/aadA2, dfrA1/aadA1, dfrA7, and arr2/blaOXA30/cmlA5/aadA2, were found in genetically unrelated isolates from 8 countries on 4 continents, which supports a role for horizontal gene transfer in the global dissemination of S. enterica multidrug resistance. Serovar Typhimurium isolates containing identical integrons with the gene cassettes blaPSE1 and aadA2 were found in 4 countries on 3 continents, which supports the role of clonal expansion. This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica.
Keyword Salmonella enterica
drug resistance
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
 
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Created: Thu, 03 Sep 2009, 08:36:08 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research