Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease

Sutherland, Greg T., Siebert, Gerhard A., Newman, Jeremy R.B., Silburn, Peter A., Boyle, Richard S., O'Sullivan, John D. and Mellick, George D. (2009) Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease. Movement Disorders, 24 3: 449-452. doi:10.1002/mds.22427


Author Sutherland, Greg T.
Siebert, Gerhard A.
Newman, Jeremy R.B.
Silburn, Peter A.
Boyle, Richard S.
O'Sullivan, John D.
Mellick, George D.
Title Haplotype Analysis of the PARK 11 Gene, GIGYF2, in Sporadic Parkinson's Disease
Formatted title
 Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Journal name Movement Disorders   Check publisher's open access policy
ISSN 1531-8257
Publication date 2009-02-15
Year available 2008
Sub-type Article (original research)
DOI 10.1002/mds.22427
Volume 24
Issue 3
Start page 449
End page 452
Total pages 4
Place of publication Malden, U.S.A.
Publisher Wiley InterScience
Language eng
Subject 1103 Clinical Sciences
1109 Neurosciences
C1
Formatted abstract
 Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.
Keyword Parkinson's disease
PD-related genes
Association
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 08:35:13 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences