Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

Harvey, D, Pointon, JJ, Sleator, C, Meenagh, A, Farrar, C, Sun, JY, Senitzer, D, Middleton, D, Brown, MA and Wordsworth, BP (2009) Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis. Annals of the Rheumatic Diseases, 68 4: 595-598. doi:10.1136/ard.2008.095927

Author Harvey, D
Pointon, JJ
Sleator, C
Meenagh, A
Farrar, C
Sun, JY
Senitzer, D
Middleton, D
Brown, MA
Wordsworth, BP
Title Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 2009-04
Year available 2008
Sub-type Article (original research)
DOI 10.1136/ard.2008.095927
Volume 68
Issue 4
Start page 595
End page 598
Total pages 4
Editor Tore K. Kvien
Place of publication United Kingdom
Publisher B M J Group
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920116 Skeletal System and Disorders (incl. Arthritis)
060406 Genetic Immunology
060407 Genome Structure and Regulation
Abstract Objectives: To assess the possible association of killer immunoglobulin-like receptor (KIR) genes, specifically KIR3DL1, KIR3DS1 and KIR3DL2, with ankylosing spondylitis (AS). Methods: 14 KIR genes were genotyped in 200 UK patients with AS and 405 healthy controls using multiplex polymerase chain reaction. Sequence-specific oligonucleotide probes were used to subtype 368 cases with AS and 366 controls for 12 KIR3DL2 alleles. Differences in KIR genotypes and KIR3DL2 allele frequencies were assessed using the χ2 test. Results: KIR3DL1 and KIR3DS1 gene frequencies were very similar in cases with AS and controls (odds ratio = 1.5, 95% confidence interval 0.8 to 3.0, and odds ratio = 1.02, 95% confidence interval 0.2 to 5.3, respectively). KIR3DL2 allele frequencies were not significantly different between cases with AS and controls. Conclusions: Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
Keyword immunoglobulin
Cutting Edge
Arthritic Pain
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 08:33:15 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute