CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking

Mahavorasirikul, Wiratchanee, Tassaneeyakul, Wichittra, Satarug, Soisagwan, Reungweerayut, Ronnatrai, Na-Bangchang, Chacrin and Na-Bangchang, Kesara (2009) CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking. European Journal of Clinical Pharmacology, 65 4: 377-384. doi:10.1007/s00228-008-0595-2


Author Mahavorasirikul, Wiratchanee
Tassaneeyakul, Wichittra
Satarug, Soisagwan
Reungweerayut, Ronnatrai
Na-Bangchang, Chacrin
Na-Bangchang, Kesara
Title CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking
Journal name European Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0031-6970
1432-1041
Publication date 2009-04
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00228-008-0595-2
Volume 65
Issue 4
Start page 377
End page 384
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract Objective To investigate the association between polymorphisms in the human CYP2A6 gene, CYP2A6 enzyme activity and the influence of cigarette smoking in a Thai population.
Methods Coumarin (5 mg capsule) was administered to 194 healthy Thai subjects. Genetic variation of the CYP2A6 gene was identified using PCR methods. The excreted dose of 7-hydroxycoumarin (as a percentage of the urine concentration) 2 h after administration was calculated as an index of coumarin metabolism.
Results The frequencies of CYP2A6 alleles *1A, *1B, *4C, *7, *8, *9 and *10 were 34.0, 35.3, 9.3, 6.4, 0.5, 12.1 and 2.4%, respectively. Of the 194 subjects tested, the number (percentages) of Thai participants classified as ultra-rapid, extensive, intermediate and poor metabolizers were 8 (4.1%), 159 (82.0%) 22 (11.3%) and five (2.6%), respectively.
Conclusion A relationship between the interindividual differences in coumarin metabolism and genetic polymorphisms of the CYP2A6 gene was observed.
Keyword Cytochrome P450
Genetic polymorphism
Genotyping–phenotyping
Coumarin 7-hydroxylation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online: 13 December 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Thu, 03 Sep 2009, 08:31:44 EST by Mr Andrew Martlew on behalf of National Res Centre For Environmental Toxicology