Reactions of the First Cisplatin Hydrolytes cis-[Pt((NH3)-N-15)(2)(H2O)Cl](+) with L-Cysteine

Hadi, S. and Appleton, T. G. (2009) Reactions of the First Cisplatin Hydrolytes cis-[Pt((NH3)-N-15)(2)(H2O)Cl](+) with L-Cysteine. Polish Journal of Chemistry, 83 3: 437-443.

Author Hadi, S.
Appleton, T. G.
Title Reactions of the First Cisplatin Hydrolytes cis-[Pt((NH3)-N-15)(2)(H2O)Cl](+) with L-Cysteine
Journal name Polish Journal of Chemistry   Check publisher's open access policy
ISSN 0137-5083
Publication date 2009-03
Sub-type Article (original research)
Volume 83
Issue 3
Start page 437
End page 443
Total pages 7
Place of publication Poland
Publisher Polskie Towarzystwo Chemiczne
Language eng
Formatted abstract
The interactions of cis-[PtCl(15NH3)2(H2O)](NO3) (2) with L-cysteine (H2cys) was investigated in aqueous solution. In this reaction, the polymeric solid was not formed and the am - mine liberation was slower than the similar reaction for cis-[Pt(15NH3)2(H2O)2](NO3) (3). It is also ob served that although in the reactions of 2 with a variety of thiols gave different ultimate product in each reaction, initially the only product observed was a platinum(II) species with chloride and the thiolate ligand bound monodentate through sulphur. In this reaction, after the formation of a species with thiolate bound monodentate cis-[PtCl(15NH3)2(Hcys-S)] (7), this initial product was then converted to some other complexes, trans-[PtCl(15NH3)(Hcys-S)2] (8), cis-[PtCl(15NH3)(Hcys-S)2] (9) and cis-[{Pt(15NH3)2Cl}2(Hcys-m-S)]2+ (10). Unlike the reactions of 2 and 3 with other thiols,the bis (thiolate) platinum(II) and dinuclear sulphur-bridged complexes were not formed in solution.
Keyword Cisplatin Hydrolytes
Cis-diamminediaquaplatinum(ii) Cation
L-cysteine
Monodentate S-bound thiolate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 03 Sep 2009, 08:28:25 EST by Mr Andrew Martlew on behalf of School of Chemistry & Molecular Biosciences