Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case control study and meta-analysis of published series

Karaderi, T., Harvey, D., Farrar, C., Appleton, L. H., Stone, M. A., Sturrock, R. D., Brown, M. A., Wordsworth, P. and Pointon, J. J. (2009) Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case control study and meta-analysis of published series. Rheumatology, 48 4: 386-389. doi:10.1093/rheumatology/ken501


Author Karaderi, T.
Harvey, D.
Farrar, C.
Appleton, L. H.
Stone, M. A.
Sturrock, R. D.
Brown, M. A.
Wordsworth, P.
Pointon, J. J.
Title Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case control study and meta-analysis of published series
Journal name Rheumatology   Check publisher's open access policy
ISSN 1462-0324
1462-0332
Publication date 2009-04
Year available 2009
Sub-type Article (original research)
DOI 10.1093/rheumatology/ken501
Volume 48
Issue 4
Start page 386
End page 389
Total pages 4
Editor F. Hiepe
Place of publication Oxford, England
Publisher Oxford University Pres
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920116 Skeletal System and Disorders (incl. Arthritis)
110322 Rheumatology and Arthritis
Formatted abstract
Objectives.
It has been shown previously that IL-23R variants are associated with AS. We conducted an extended analysis in the UK population and a meta-analysis with the previously published studies, in order to refine these IL-23R associations with AS.

Methods.
The UK casecontrol study included 730 new cases and 1331 healthy controls. In the extended study, the 730 cases were combined with 1088 published cases. Allelic associations were analysed using contingency tables. In the meta-analysis, 3482 cases and 3150 controls from four different published studies and the new UK cases were combined. DerSimonianLaird test was used to calculate random effects pooled odds ratios (ORs).

Results.
In the UK casecontrol study with new cases, four of the eight SNPs showed significant associations, whereas in the extended UK study, seven of the eight IL-23R SNPs showed significant associations (P 0.05) with AS, maximal with rs11209032 (P 10(5), OR 1.3), when cases with IBD and/or psoriasis were excluded. The meta-analysis showed significant associations with all eight SNPs; the strongest associations were again seen not only with rs11209032 (P 4.06 10(9), OR 1.2) but also with rs11209026 (P 10(10), OR 0.6).

Conclusions.
IL-23R polymorphisms are clearly associated with AS, but the primary causal association(s) is(are) still not established. These polymorphisms could contribute either increased or decreased susceptibility to AS; functional studies will be required for their full evaluation. Additionally, observed stronger associations with SNPs rs11209026 and rs11465804 upon exclusion of IBD and/or psoriasis cases may represent an independent association with AS.
Keyword IL-23 receptor
Autoimmune Inflammation
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 03 Sep 2009, 08:26:23 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute