Discorhabdins Revisited: Cytotoxic Alkaloids from Southern Australian Marine Sponges of the Genera Higginsia and Spongosorites

El-Naggar, M and Capon, R. J. (2009) Discorhabdins Revisited: Cytotoxic Alkaloids from Southern Australian Marine Sponges of the Genera Higginsia and Spongosorites. JOURNAL OF NATURAL PRODUCTS, 72 3: 460-464. doi:10.1021/np8007667


Author El-Naggar, M
Capon, R. J.
Title Discorhabdins Revisited: Cytotoxic Alkaloids from Southern Australian Marine Sponges of the Genera Higginsia and Spongosorites
Formatted title
Discorhabdins Revisited: Cytotoxic Alkaloids from Southern Australian Marine Sponges of the Genera Higginsia and Spongosorites
Journal name JOURNAL OF NATURAL PRODUCTS   Check publisher's open access policy
ISSN 0163-3864
Publication date 2009-03-27
Year available 2009
Sub-type Article (original research)
DOI 10.1021/np8007667
Volume 72
Issue 3
Start page 460
End page 464
Total pages 5
Editor A. Kinghorn Douglas
Place of publication Washington DC, U.S.A.
Publisher American Chemical Society
Collection year 2010
Language eng
Subject C1
970101 Expanding Knowledge in the Mathematical Sciences
030502 Natural Products Chemistry
Abstract Chemical analysis of southern Australian marine sponges of the genera Higginsia and Spongosorites has yielded examples of the discorhabdin class of alkaloids. These include the known metabolites (+)-discorhabdin A (1), (+)-discorhabdin D (2), makaluvamine J (6), and damirone A (7), together with four new analogues, (+)-dihydrodiscorhabdin A (3), (+)-debromodiscorhabdin A (4), (+)-dihydrodiscorhabdin L (8), and (+)-discorhabdin X (5), with the latter compound being the first reported example of a thio heterocycle flanked by oxo-thio-acetal and azo-thio-acetal functionalities. Structures for the new compounds were assigned on the basis of detailed spectroscopic interpretation.
Formatted abstract
Chemical analysis of southern Australian marine sponges of the genera Higginsia and Spongosorites has yielded examples of the discorhabdin class of alkaloids. These include the known metabolites (+)-discorhabdin A (1), (+)-discorhabdin D (2), makaluvamine J (6), and damirone A (7), together with four new analogues, (+)-dihydrodiscorhabdin A (3), (+)-debromodiscorhabdin A (4), (+)-dihydrodiscorhabdin L (8), and (+)-discorhabdin X (5), with the latter compound being the first reported example of a thio heterocycle flanked by oxo-thio-acetal and azo-thio-acetal functionalities. Structures for the new compounds were assigned on the basis of detailed spectroscopic interpretation.
Keyword LATRUNCULIA-BREVIS
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes First published online February 18, 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 03 Sep 2009, 08:24:45 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience