Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages

Hoppe, C. C., Moritz, K. M., Fitzgerald, S. M., Bertram, J. F. and Evans, R. G. (2009) Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages. Physiological Research, 58 1: 69-75.

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Author Hoppe, C. C.
Moritz, K. M.
Fitzgerald, S. M.
Bertram, J. F.
Evans, R. G.
Title Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages
Journal name Physiological Research   Check publisher's open access policy
ISSN 0862-8408
0369-9463
Publication date 2009
Year available 2008
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 58
Issue 1
Start page 69
End page 75
Total pages 7
Place of publication Prague, Czech Republic
Publisher Prague : Institute of Physiology, Czech Academy of Sciences
Language eng
Abstract The novel environment of a metabolic cage can be stressful for rodents, but few studies have attempted to quantify this stress response. Therefore, we determined the effects on mean arterial pressure (MAP) and heart rate (HR), of placing mice of both sexes in metabolism cages for 2 days. After surgical implantation of a carotid artery catheter mice recovered individually in standard cages for 5 days. Mice then spent 2 days in metabolism cages. MAP and HR were monitored in the standard cage on Day 5 and in metabolism cages on Days 6-7. MAP increased by 18±3 and 22±4 %, while HR increased by 27±4 and 27±6 %, in males and females, respectively, during the first hours after cage switch. MAP decreased to baseline in the fourth and eighth h following metabolism cage switch in males and females, respectively. However, HR remained significantly elevated in both sexes during the entire two-day period in metabolism cages. Females had lower MAP than males both pre- and postmetabolism cage switch, but there were no sex differences in HR. These results demonstrate sustained changes in cardiovascular function when mice are housed in metabolism cages, which could potentially affect renal function.
Keyword Mice
Stress-like responses
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 03 Sep 2009, 08:23:38 EST by Mr Andrew Martlew on behalf of Faculty Of Health Sciences