Associations between age, body size and nephron number with individual glomerular volumes in urban West African males

McNamara, Bridgette J., Diouf, Boucar, Hughson, Michael D., Hoy, Wendy E. and Bertram, John F. (2009) Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrology Dialysis Transplantation, 24 5: 1500-1506. doi:10.1093/ndt/gfn636


Author McNamara, Bridgette J.
Diouf, Boucar
Hughson, Michael D.
Hoy, Wendy E.
Bertram, John F.
Title Associations between age, body size and nephron number with individual glomerular volumes in urban West African males
Journal name Nephrology Dialysis Transplantation   Check publisher's open access policy
ISSN 0931-0509
1460-2385
Publication date 2009-05
Year available 2008
Sub-type Article (original research)
DOI 10.1093/ndt/gfn636
Volume 24
Issue 5
Start page 1500
End page 1506
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background. Glomerulomegaly has been associated with an increased risk of renal disease. Few reports have investigated the heterogeneity of glomerular size within kidneys and associated risk factors. This study measured the individual glomerular volume (IGV) of 720 non-sclerotic glomeruli in kidneys of adult West African males, and investigated associations of IGV with age, total glomerular (nephron) number and body surface area (BSA).
Methods. IGVs were determined in the kidneys of 24 Senegalese males from two age groups (12 subjects aged 20– 30 years and 12 subjects aged 50–70 years). Subjects were randomly chosen at autopsies performed at Le Dantec Hospital in Dakar. Volumes of 30 glomeruli per subject were determined using the disector/Cavalieri stereological method.
Results. IGVs ranged from 1.31 × 106 μm3 to 12.40 × 106 μm3 (a 9.4-fold variation). IGV varied up to 5.3-fold within single kidneys. The trimmed range of IGV within subjects (10th to 90th percentile of IGV) was directly correlated with median glomerular size. The mean and standard deviation (SD) of IGV did not differ significantly between age groups or between subjects with higher (≥1.78 m2) and lower BSA (<1.78 m2). In older subjects the SD of IGV was significantly and directly correlated with BSA. Kidneys with less than 1 million nephrons had significantly larger mean IGV than kidneys with more than 1 million nephrons, and the trimmed range of IGVs within subjects was inversely correlated with total glomerular number.
Conclusion. There was a considerable variation in IGV within kidneys of Senegalese males at autopsy. The heterogeneity of IGV was increased in association with low nephron number and increased BSA, with more pronounced effects in older subjects.
Keyword Glomerular size
Glomerular volume
Heterogeneity
Nephron number
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes First published online: November 21, 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 08:15:27 EST by Mr Andrew Martlew on behalf of Medicine - Royal Brisbane and Women's Hospital