Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females

Harris, Thomas A., Healy, Genevieve N., Colditz, Paul B. and Lingwood, Barbara E. (2009) Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females. Pediatric Research, 65 5: 504-508. doi:10.1203/PDR.0b013e31819d9747


Author Harris, Thomas A.
Healy, Genevieve N.
Colditz, Paul B.
Lingwood, Barbara E.
Title Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 2009-05
Year available 2009
Sub-type Article (original research)
DOI 10.1203/PDR.0b013e31819d9747
Volume 65
Issue 5
Start page 504
End page 508
Total pages 5
Editor Sherin U Devaskar
Place of publication Baltimore, MD, United States of America
Publisher Lippincott Williams & Wilkins
Collection year 2010
Language eng
Subject 111403 Paediatrics
C1
920501 Child Health
Abstract The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur in the presence of hypoxia in the neonatal rat. The aim of this study was to determine the characteristics and occurrence of type-3 waves in the neonatal piglet and any relationship to neurologic damage after acute global hypoxia. Hypoxia/hypercarbia was induced in 32 anesthetized piglets by reducing the fraction of inspired oxygen to 0.1 and the ventilation rate from 30 to 10 breaths per minute for 45 min. The degree of neurologic damage was assessed using both physiologic (EEG amplitude and cerebral impedance at 6 h posthypoxia) and structural (microtubule associated protein-2 immunohistochemistry) markers. Type-3 waves in cardiovascular function occurred in 56% of animals. An oscillating pattern was significantly associated with less neurologic damage (p = 0.01) and a lower duration of hypotension during hypoxia (p = 0.02), and occurred more frequently in females (p = 0.024).
Keyword hypoxia
Perinatal Asphyxia
Neurodevelopment
Cardiovascular Function
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
School of Public Health Publications
 
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Created: Thu, 03 Sep 2009, 08:15:23 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research