Cottoquinazoline A and Cotteslosins A and B, metabolites from an australian marine-derived strain of aspergillus versicolor

Fremlin, L. J., Piggott, A. M., Lacey, E and Capon, R. J. (2009) Cottoquinazoline A and Cotteslosins A and B, metabolites from an australian marine-derived strain of aspergillus versicolor. Journal of Natural Products, 72 4: 666-670. doi:10.1021/np800777f


Author Fremlin, L. J.
Piggott, A. M.
Lacey, E
Capon, R. J.
Title Cottoquinazoline A and Cotteslosins A and B, metabolites from an australian marine-derived strain of aspergillus versicolor
Formatted title
Cottoquinazoline A and Cotteslosins A and B, metabolites from an australian marine-derived strain of aspergillus versicolor
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2009-04-24
Year available 2009
Sub-type Article (original research)
DOI 10.1021/np800777f
Volume 72
Issue 4
Start page 666
End page 670
Total pages 5
Editor A. Kinghorn Douglas
Place of publication Washington , DC, U.S.A.
Publisher American Chemical Society
Collection year 2010
Language eng
Subject C1
970101 Expanding Knowledge in the Mathematical Sciences
030502 Natural Products Chemistry
Abstract An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (−)-cyclopenol, and viridicatol, along with a new alkaloid, cottoquinazoline A (1), and two new cyclopentapeptides, cotteslosins A (2) and B (3). Structures for 1−3 and the known compounds were determined by spectroscopic analysis. The absolute configurations of 1−3 were addressed by chemical degradation and application of the C3 Marfey’s method. The use of “cellophane raft” high-nutrient media as a device for up-regulating secondary metabolite diversity in marine-derived fungi is discussed. The antibacterial properties displayed by A. versicolor (MST-MF495) were attributed to the phenols violaceol I, violaceol II, and diorcinol, while cotteslosins 2 and 3 were identified as weak cytotoxic agents.
Formatted abstract
An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (−)-cyclopenol, and viridicatol, along with a new alkaloid, cottoquinazoline A (1), and two new cyclopentapeptides, cotteslosins A (2) and B (3). Structures for 1−3 and the known compounds were determined by spectroscopic analysis. The absolute configurations of 1−3 were addressed by chemical degradation and application of the C3 Marfey’s method. The use of “cellophane raft” high-nutrient media as a device for up-regulating secondary metabolite diversity in marine-derived fungi is discussed. The antibacterial properties displayed by A. versicolor (MST-MF495) were attributed to the phenols violaceol I, violaceol II, and diorcinol, while cotteslosins 2 and 3 were identified as weak cytotoxic agents.
Keyword Sansalvamide-A Derivatives
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes First published online February 26, 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 03 Sep 2009, 08:13:13 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience