Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population

Mackenzie, Jason, Tajouri, Lotti, Szvetko, Attila, Weth, Verena, Moreau, Julie, Greer, Judith M., Csurhes, Peter A., Pender, Michael P. and Griffiths, Lyn R. (2009) Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. Journal of the Neurological Sciences, 280 1-2: 62-64. doi:10.1016/j.jns.2009.01.026

Author Mackenzie, Jason
Tajouri, Lotti
Szvetko, Attila
Weth, Verena
Moreau, Julie
Greer, Judith M.
Csurhes, Peter A.
Pender, Michael P.
Griffiths, Lyn R.
Title Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 0022-510X
Publication date 2009-05-15
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jns.2009.01.026
Volume 280
Issue 1-2
Start page 62
End page 64
Total pages 3
Editor Robert P. Lisak
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2010
Language eng
Subject C1
110706 Immunogenetics (incl. Genetic Immunology)
110904 Neurology and Neuromuscular Diseases
920111 Nervous System and Disorders
Formatted abstract
Objective: To examine a polymorphism within the 3' untranslated region of the leukemia inhibitory factor gene for an association with multiple sclerosis within an Australian case-control population.

Methods: A test group of 121 unrelated multiple sclerosis patients, of Caucasian origin, and 121 controls, matched for ethnicity, sex and age (+/-5 years) were included in the study. The LIF 3' UTR StuI polymorphism was genotyped by restriction fragment length polymorphism analysis. Statistical analysis of genotype and allele frequencies included Hardy-Weinberg law and conventional contingency table analysis incorporating the standard chi-squared test for independence.

Results: Allelic and genotype frequencies did not demonstrate a significant association between the case and control groups for the tested LIF 3' UTR StuI polymorphism.

: The results indicate that the LIF 3' UTR StuI polymorphism is not associated with multiple sclerosis, however we cannot exclude the hypothesis that other polymorphic alleles of LIF could be implicated in MS susceptibility.
Keyword Multiple sclerosis
Leukaemia Inhibitory Factor
Restriction Fragment Length Polymorphism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
School of Medicine Publications
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Created: Thu, 03 Sep 2009, 08:11:28 EST by Mr Andrew Martlew on behalf of UQ Centre for Clinical Research