Characterizing Microporous PCL Matrices for Application of Tissue Engineering

Yeh, Chih-Chang, Li, Yun-Ting, Chiang, Pei Hsiu, Huang, Chun-Hao, Wang, Yiwei and Chang, Hsin-I. (2009) Characterizing Microporous PCL Matrices for Application of Tissue Engineering. Journal of Medical and Biological Engineering, 29 2: 92-97.

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Author Yeh, Chih-Chang
Li, Yun-Ting
Chiang, Pei Hsiu
Huang, Chun-Hao
Wang, Yiwei
Chang, Hsin-I.
Title Characterizing Microporous PCL Matrices for Application of Tissue Engineering
Journal name Journal of Medical and Biological Engineering   Check publisher's open access policy
ISSN 1609-0985
Publication date 2009
Sub-type Article (original research)
Volume 29
Issue 2
Start page 92
End page 97
Total pages 6
Place of publication Taiwan, Republic of China
Publisher Zhonghua Minguo Shengwu Yixue Gongcheng Xuehui
Language eng
Formatted abstract Polycaprolactone (PCL) is a semicrystalline polymer and has been fabricated into various forms such as membranes, films, matrices, fibers, micro/nano particles, capsules and reservoir devices for drug delivery and tissue engineering due to its good biocompatibility. In this study, microporous PCL matrices (MPM) with 10-20 μm pores on the surface were produced using various PCL molecular weight from 40,000 to 80,000 by precipitation casting method. The tensile strength of MPM prepared using 12.5% w/v polymer solution tended to increase from 0.83 Mpa to 1.42 Mpa and the elongation rate was improved from 35.2% to 117.8% when increasing PCL molecular weight. In addition, there was also a significant increase in compression and bending strength. MPM exhibited high porosity up to 72.4%, and the porosity of MPM reduced with rising of PCL solution concentration and molecular weight. The crystallinity of MPM prepared using 12.5% CAPA6400 polymer solution was measured at approximately 67%, while molecular weight showed a minor effect on the crystallinity of MPM. In cytocompatibility studies, MPM prepared using CAPA 6500 and 6800 showed higher cell attachment than CAPA 6400. Three-point bending test also showed that MPM prepared with low molecular weight (CAPA 6400) had a higher fragility for easy breakdown of tissue scaffold. Therefore, MPM prepared using CAPA 6500 (or CAPA 6800) may be more suitable tissue scaffold for biomedical application. Herein, we report that processing parameters such as polymer solution concentrations and molecular weight could modify the porosity and stiffness of MPM and then influence cell/biomaterial interaction.
Keyword Polycaprolactone
Tissue engineering
Cytocompatibility
Fibroblast
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Thu, 03 Sep 2009, 08:02:16 EST by Mr Andrew Martlew on behalf of School of Pharmacy