L-Dopa modulates functional connectivity in striatal cognitive and motor networks: A double-blind placebo-controlled study

Kelly, C., de Zubicaray, G., Di Martino, A., Copland, David A., Reiss, P.T., Klein, D.F., Castellanos, F.X., Milham, M.P. and McMahon, K. (2009) L-Dopa modulates functional connectivity in striatal cognitive and motor networks: A double-blind placebo-controlled study. Journal of Neuroscience, 29 22: 7364-7378. doi:10.1523/JNEUROSCI.0810-09.2009

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Author Kelly, C.
de Zubicaray, G.
Di Martino, A.
Copland, David A.
Reiss, P.T.
Klein, D.F.
Castellanos, F.X.
Milham, M.P.
McMahon, K.
Title L-Dopa modulates functional connectivity in striatal cognitive and motor networks: A double-blind placebo-controlled study
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
1529-2401
Publication date 2009-06-03
Year available 2009
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.0810-09.2009
Open Access Status File (Publisher version)
Volume 29
Issue 22
Start page 7364
End page 7378
Total pages 14
Editor John H R Maunsell
Place of publication U.S.A
Publisher Society for Neuroscience
Collection year 2010
Language eng
Subject C1
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
110320 Radiology and Organ Imaging
970111 Expanding Knowledge in the Medical and Health Sciences
920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
170205 Neurocognitive Patterns and Neural Networks
110999 Neurosciences not elsewhere classified
Abstract Functional connectivity (FC) analyses of resting-state fMRI data allow for the mapping of large-scale functional networks, and provide a novel means of examining the impact of dopaminergic challenge. Here, using a double-blind, placebo-controlled design, we examined the effect of L-dopa, a dopamine precursor, on striatal resting-state FC in 19 healthy young adults. We examined the FC of 6 striatal regions of interest (ROIs) previously shown to elicit networks known to be associated with motivational, cognitive and motor subdivisions of the caudate and putamen (Di Martino et al., 2008). In addition to replicating the previously demonstrated patterns of striatal FC, we observed robust effects of L-dopa. Specifically, L-dopa increased FC in motor pathways connecting the putamen ROIs with the cerebellum and brainstem. Although L-dopa also increased FC between the inferior ventral striatum and ventrolateral prefrontal cortex, it disrupted ventral striatal and dorsal caudate FC with the default mode network. These alterations in FC are consistent with studies that have demonstrated dopaminergic modulation of cognitive and motor striatal networks in healthy participants. Recent studies have demonstrated altered resting state FC in several conditions believed to be characterized by abnormal dopaminergic neurotransmission. Our findings suggest that the application of similar experimental pharmacological manipulations in such populations may further our understanding of the role of dopaminergic neurotransmission in those conditions.
Keyword ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
Behavioral
Systems
Cognitive
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Centre for Advanced Imaging Publications
 
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Created: Thu, 03 Sep 2009, 08:01:58 EST by Mr Andrew Martlew on behalf of Centre For Magnetic Resonance