Genetic variation in female BMI increases with number of children born but failure to replicate association between GN beta 3 variants and increased BMI in parous females

Cornes, Belinda K., Medland, Sarah E., Lind, Penelope A., Nyholt, Dale R., Montgomery, Grant W. and Martin, Nicholas G. (2009) Genetic variation in female BMI increases with number of children born but failure to replicate association between GN beta 3 variants and increased BMI in parous females. Twin Research and Human Genetics, 12 3: 276-285. doi:10.1375/twin.12.3.276


Author Cornes, Belinda K.
Medland, Sarah E.
Lind, Penelope A.
Nyholt, Dale R.
Montgomery, Grant W.
Martin, Nicholas G.
Title Genetic variation in female BMI increases with number of children born but failure to replicate association between GN beta 3 variants and increased BMI in parous females
Formatted title
Genetic variation in female BMI increases with number of children born but failure to replicate association between GNβ3 variants and increased BMI in parous females
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2009-06
Year available 2009
Sub-type Article (original research)
DOI 10.1375/twin.12.3.276
Volume 12
Issue 3
Start page 276
End page 285
Total pages 10
Editor Katherine M. Kirk
Nicholas G. Martin
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2010
Language eng
Subject C1
920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified
110311 Medical Genetics (excl. Cancer Genetics)
Formatted abstract
Objective: As post-pregnancy weight retention in women is a risk factor for obesity later in life, we assessed the changes in magnitude of genetic and environmental variation in BMI due to parity in an Australian female sample, comprising 11,915 female twins and their sisters.

Results: Total variance of BMI increased with parity, primarily driven by an increase in nonadditive genetic variance. This finding was of particular interest given Gutersohn et al's (2000) report of recessive association between post-partum weight retention and the 825T allele of the GNβ3 gene (rs5443) at 12p13.31. Hence, we attempted to replicate this association and test an additional three SNPs also located near or on GNβ3 (rs10744716 (upstream), rs5442 (exon 10), rs5446 (exon 11)) in a sample of 3131 females and 1693 males from 2585 twin families. No association was found between these SNPs among females, even when allowing for a genotype by parity effect. However, a significant association was observed among males for rs10744716 (χ22 = 10.22, p = 0.006; effect size = 0.47kg/m2), representing a novel association between a region upstream of GNβ3 and male BMI.
Keyword Body Mass Index (BMI)
Guanine nucleotide binding protein 3 (GNβ3)
Association
Parity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 08:01:13 EST by Mr Andrew Martlew on behalf of Medicine - Royal Brisbane and Women's Hospital