Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?

Greer, R. M, McErlean, P., Arden, K. E., Faux, C. E., Nitsche, A., Lambert, S. B., Nissen, M. D., Sloots, T. P. and Mackay, I. M. (2009) Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?. Journal of Clinical Virology, 45 1: 10-15. doi:10.1016/j.jcv.2009.03.008

Author Greer, R. M
McErlean, P.
Arden, K. E.
Faux, C. E.
Nitsche, A.
Lambert, S. B.
Nissen, M. D.
Sloots, T. P.
Mackay, I. M.
Title Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?
Journal name Journal of Clinical Virology   Check publisher's open access policy
ISSN 1386-6532
Publication date 2009-05
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jcv.2009.03.008
Volume 45
Issue 1
Start page 10
End page 15
Total pages 6
Editor Dr. B. Carman
Place of publication Netherlands
Publisher Elseiver BV
Collection year 2010
Language eng
Subject 060502 Infectious Agents
060506 Virology
920115 Respiratory System and Diseases (incl. Asthma)
920109 Infectious Diseases
Formatted abstract
Background: Human rhinoviruses (HRVs) are often concurrently detected with other viruses found in the respiratory tract because of the high total number of HRV infections occurring throughout the year. This feature has previously relegated HRVs to being considered passengers in acute respiratory infections. HRVs remain poorly characterized and are seldom included as a target in diagnostic panels despite their pathogenic potential. infection-associated healthcare expenditure and relatively unmoderated elicitation
of an antiviral state.

Objectives: To test the hypothesis that respiratory viruses are proportionately more or less likely to co- occur. particularly the HRVs.

Study design: Retrospective peR-based analyses of 1247 specimens for 17 viruses. including HRV strains.

identified 131 specimens containing two or more targets. We investigated the proportions of co-detections and compared the.proportion of upper vs.lower respiratory tract presentations in the HRV positive group. Both univariate contingency table and multivariate logistic regression analyses were conducted to identify trends of association among the viruses present in co-detections.

Results: Many of the co-detections occurred in patterns. In particular, HRV detection was associated with a reduced probability of detecting human adenoviruses, coronaviruses, bocavirus, metapneumovirus, respiratory syncytial virus, parainfluenza virus, influenza A virus, and the polyomaviruses KIPyV and WUPyV (p ≤0.05). No single HRV species nor cluster of particular strains predominated.

Conclusions: HRVs were proportionately under-represented among viral co-detections. For some period, HRVs may render the host less likely to be infected by other viruses.

© 2009 Elsevier B.V. All rights reserved.

Keyword Rhinovirus
Bronchial epithelial cells
Acute respiratory tract infection
Innate immunity
Protective effect
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 60 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 63 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 03 Sep 2009, 07:59:59 EST by Mr Andrew Martlew on behalf of Clinical Medical Virology Centre