Small RNAs derived from snoRNAs

Taft, Ryan J., Glazov, Evgeny A., Lassmann, Timo, Hayashizaki, Yoshihide, Carninci, Piero and Mattick, John S. (2009) Small RNAs derived from snoRNAs. RNA, 15 7: 1233-1240. doi:10.1261/rna.1528909

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Author Taft, Ryan J.
Glazov, Evgeny A.
Lassmann, Timo
Hayashizaki, Yoshihide
Carninci, Piero
Mattick, John S.
Title Small RNAs derived from snoRNAs
Journal name RNA   Check publisher's open access policy
ISSN 1355-8382
1469-9001
Publication date 2009-07
Year available 2009
Sub-type Article (original research)
DOI 10.1261/rna.1528909
Open Access Status File (Publisher version)
Volume 15
Issue 7
Start page 1233
End page 1240
Total pages 8
Editor Timothy W. Nilsen
Place of publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2010
Language eng
Abstract Small nucleolar RNAs (snoRNAs) guide RNA modification and are localized in nucleoli and Cajal bodies in eukaryotic cells. Components of the RNA silencing pathway associate with these structures, and two recent reports have revealed that a human and a protozoan snoRNA can be processed into miRNA-like RNAs. Here we show that small RNAs with evolutionary conservation of size and position are derived from the vast majority of snoRNA loci in animals (human, mouse, chicken, fruit fly), Arabidopsis, and fission yeast. In animals, sno-derived RNAs (sdRNAs) from H/ACA snoRNAs are predominantly 20–24 nucleotides (nt) in length and originate from the 3′ end. Those derived from C/D snoRNAs show a bimodal size distribution at ∼17–19 nt and >27 nt and predominantly originate from the 5′ end. SdRNAs are associated with AGO7 in Arabidopsis and Ago1 in fission yeast with characteristic 5′ nucleotide biases and show altered expression patterns in fly loquacious and Dicer-2 and mouse Dicer1 and Dgcr8 mutants. These findings indicate that there is interplay between the RNA silencing and snoRNA-mediated RNA processing systems, and that sdRNAs comprise a novel and ancient class of small RNAs in eukaryotes.
Keyword small nucleolar RNA
microRNA
deep sequencing
Argonaute
Dicer
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Thu, 03 Sep 2009, 07:56:54 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience