Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis

Hannawi, Suad, Marwick, Thomas and Thomas, Ranjeny (2009) Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis. Arthritis Research and Therapy, 11 2: R51.1-R51.7. doi:10.1186/ar2668


Author Hannawi, Suad
Marwick, Thomas
Thomas, Ranjeny
Title Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1465-9905
1478-6362
1478-6354
Publication date 2009-04-06
Year available 2009
Sub-type Article (original research)
DOI 10.1186/ar2668
Open Access Status DOI
Volume 11
Issue 2
Start page R51.1
End page R51.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2010
Language eng
Formatted abstract
Introduction
Patients with recent-onset rheumatoid arthritis (RA) have impaired brachial artery endothelial function compared with controls matched for age, sex and cardiovascular risk factors. The present study examined endothelium-dependent (flow-mediated dilatation (FMD)) and independent (glyceryl trinitrate (GTN)-mediated dilatation (GMD)) structural responses in early RA patients, and determined progress over one year.

Methods
Brachial artery FMD and GMD and carotid intima media thickness (cIMT) were studied using ultrasound in 20 patients diagnosed with early RA in whom symptoms had been present for less than 12 months, and in 20 control subjects matched for age, sex and established cardiovascular risk factors. FMD and GMD were re-assessed after 12 months in RA patients and the change in each parameter was calculated. Data were analysed by univariate regression.

Results
Mean FMD and GMD were significantly lower in early RA patients at baseline than in controls, but each parameter significantly improved in one year. FMD and GMD responses were positively associated with each other. Patients' age, C-reactive protein (CRP) level and cIMT at baseline and CRP level at one year, were negatively associated with change in brachial responses in one year.

Conclusions
Patients with recent-onset RA have altered brachial artery responses signifying both functional and structural abnormalities. However, early control of inflammation may reduce arterial dysfunction and thus the tendency for atherosclerotic progression.
Keyword Modifying antirheumatic drugs
Intima-media thickness
Low disease activity
Endothelial dysfunction
Atherosclerotic disease
Cardiovascular events
Microvascular dysfunction
Dependent dilatation
Combination therapy
Young patients
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number R51 as epublished

 
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Created: Thu, 03 Sep 2009, 07:56:30 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute