MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

Bastiani, M, Liu, L, Hill, M. M., Jedrychowski, M. P., Nixon, S. J., Lo, H. P., Abankwa, D, Luetterforst, R, Fernandez-Rojo, M, Breen, M. R., Gygi, S. P., Vinten, J, Walser, P. J., North, K. N., Hancock, J. F., Pilch, P. F. and Parton, R. G. (2009) MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. The Journal of Cell Biology, 185 7: 1259-1273. doi:10.1083/jcb.200903053

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Author Bastiani, M
Liu, L
Hill, M. M.
Jedrychowski, M. P.
Nixon, S. J.
Lo, H. P.
Abankwa, D
Luetterforst, R
Fernandez-Rojo, M
Breen, M. R.
Gygi, S. P.
Vinten, J
Walser, P. J.
North, K. N.
Hancock, J. F.
Pilch, P. F.
Parton, R. G.
Title MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
Journal name The Journal of Cell Biology   Check publisher's open access policy
ISSN 0021-9525
1540-8140
Publication date 2009-06
Sub-type Article (original research)
DOI 10.1083/jcb.200903053
Open Access Status File (Publisher version)
Volume 185
Issue 7
Start page 1259
End page 1273
Total pages 15
Editor Tom Misteli
Place of publication New York, NY, United States
Publisher Rockefeller University Press
Collection year 2010
Language eng
Abstract Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein.
Q-Index Code C1
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Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 115 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 07:55:56 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience